d-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI).

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Gynecologic and Obstetric Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI:10.1159/000536081
Simona Dinicola, Vittorio Unfer, Christophe O Soulage, Maria Isidora Margarita Yap-Garcia, Arturo Bevilacqua, Salvatore Benvenga, Daniele Barbaro, Artur Wdowiak, Maurizio Nordio, Didier Dewailly, Marialuisa Appetecchia, Cesare Aragona, Maria Salomè Bezerra Espinola, Mariano Bizzarri, Pietro Cavalli, Annamaria Colao, Rosario D'Anna, Mónica Hebe Vazquez-Levin, Imelda Hernàndez Marin, Zdravko Kamenov, Antonio Simone Laganà, Giovanni Monastra, Mario Montanino Oliva, Ali Cenk Özay, Basilio Pintaudi, Giuseppina Porcaro, Olga Pustotina, Lali Pkhaladze, Nikos Prapas, Scott Roseff, Saghar Salehpour, Annarita Stringaro, Marat Tugushev, Virginia Unfer, Ivana Vucenik, Fabio Facchinetti
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引用次数: 0

Abstract

Background: d-Chiro-inositol is a natural molecule that, in association with its well-studied isomer myo-inositol, may play a role in treating various metabolic and gynecological disorders.

Objectives: This perspective seeks to explore the mechanisms and functions of d-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation.

Methods: A narrative review of all the relevant papers known to the authors was conducted.

Outcome: d-Chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue transdifferentiation. These different modes of action have potential applications in a variety of therapeutic fields, including PCOS, dysmetabolism, obesity, hypoestrogenic/hyperandrogenic disorders, and bone health.

Conclusions: d-Chiro-inositol mode of action has been studied in detail in recent years, resulting in a clear differentiation between d-chiro-inositol and its isomer myo-inositol. The insulin-sensitizing activities of d-chiro-inositol are well understood; however, its potential applications in other fields, in particular obesity and hyperestrogenic/hypoandrogenic disorders in men and women, represent promising avenues of research that require further clinical study.

临床实践中的 D-iro-肌醇:肌醇在基础和临床研究中的应用专家组(EGOI)的观点。
背景:D-螺肌醇是一种天然分子,它与已被广泛研究的同分异构体肌醇一起,可在治疗各种代谢和妇科疾病中发挥作用:本视角旨在探讨 D-螺肌醇的机制和功能,为讨论其在临床实践中的应用奠定基础,涉及代谢紊乱、肥胖和激素调节失调等方面:方法:对作者已知的所有相关论文进行叙述性综述:结果:D-螺-肌醇通过多种机制发挥作用,除了调节白色脂肪组织/棕色脂肪组织的反式分化外,还可作为胰岛素增敏剂、抑制芳香化酶的转录。这些不同的作用模式可应用于多个治疗领域,包括结论:近年来对 D-螺肌醇的作用模式进行了详细研究,结果明确区分了 D-螺肌醇及其异构体肌醇。D-chiro -肌醇的胰岛素增敏活性已广为人知,但其在其他领域的潜在应用,尤其是男性和女性肥胖症和高雌激素/低雌激素失调症,仍是有希望的研究方向,需要进一步的临床研究。
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来源期刊
CiteScore
4.20
自引率
4.80%
发文量
44
审稿时长
6-12 weeks
期刊介绍: This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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