Precision Medicine in Rheumatology: The Promise of Ultrasound-Guided Synovial Biopsy, Barriers to Its Implementation in the United States, and Proposed Solutions.

IF 5.7 2区医学 Q1 RHEUMATOLOGY

Current Rheumatology Reports Pub Date : 2024-06-01 Epub Date: 2024-02-20 DOI:10.1007/s11926-024-01138-9

Diane Lewis Horowitz, Arthur M Mandelin, Darren Tabechian, Ami Ben-Artzi

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Abstract

Purpose of review: In the clinical evaluation of inflammatory arthritis and the research into its pathogenesis, there is a growing role for the direct analysis of synovial tissue. Over the years, various biopsy techniques have been used to obtain human synovial tissue samples, and there have been progressive improvements in the safety, tolerability, and utility of the procedure.

Recent findings: The latest advancement in synovial tissue biopsy techniques is the use of ultrasound imaging to guide the biopsy device, along with evolution in the characteristics of the device itself. While ultrasound guided synovial biopsy (UGSB) has taken a strong foothold in Europe, the procedure is still relatively new to the United States of America (USA). In this paper, we describe the expansion of UGSB in the USA, elucidate the challenges faced by rheumatologists developing UGSB programs in the USA, and describe several strategies for overcoming these challenges.

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风湿病学中的精准医学：超声引导滑膜活检的前景、在美国实施的障碍和建议的解决方案。

综述的目的：在炎症性关节炎的临床评估和发病机制研究中，直接分析滑膜组织的作用越来越大。多年来，各种活检技术已被用于获取人体滑膜组织样本，而且该方法的安全性、耐受性和实用性也在逐步提高：滑膜组织活检技术的最新进展是使用超声波成像引导活检设备，同时设备本身的特性也在不断改进。虽然超声引导滑膜活检术（UGSB）已在欧洲站稳了脚跟，但在美利坚合众国（U.S. USA），这种手术仍相对较新。在本文中，我们将介绍超声引导滑膜活检在美国的推广情况，阐明风湿病学家在美国开展超声引导滑膜活检项目所面临的挑战，并介绍克服这些挑战的几种策略。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.