The role of proteomics in acute pancreatitis: new and old knowledge.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI:10.1080/14789450.2024.2320810

Peng Ge, Yalan Luo, Guixin Zhang, Hailong Chen

{"title":"The role of proteomics in acute pancreatitis: new and old knowledge.","authors":"Peng Ge, Yalan Luo, Guixin Zhang, Hailong Chen","doi":"10.1080/14789450.2024.2320810","DOIUrl":null,"url":null,"abstract":"Introduction: Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to 35%. There is an urgent need to thoroughly understand the molecular phenotypes of SAP resulting from diverse etiologies. The field of translational research on AP has seen the use of several innovative proteomic methodologies via the ongoing improvement of isolation, tagging, and quantification methods.Areas covered: This paper provides a comprehensive overview of differentially abundant proteins (DAPs) identified in AP by searching the PubMed/MEDLINE database (2003-2023) and adds significantly to the current theoretical framework.Expert opinion: DAPs for potentially diagnosing AP based on proteomic identification need to be confirmed by multi-center studies that include larger samples. The discovery of DAPs in various organs at different AP stages via proteomic technologies is essential better to understand the pathophysiology of AP-related multiple organ dysfunction syndrome. Regarding the translational research of AP, novel approaches like single-cell proteomics and imaging using mass spectrometry may be used as soon as they become available.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"115-123"},"PeriodicalIF":3.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Proteomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/14789450.2024.2320810","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to 35%. There is an urgent need to thoroughly understand the molecular phenotypes of SAP resulting from diverse etiologies. The field of translational research on AP has seen the use of several innovative proteomic methodologies via the ongoing improvement of isolation, tagging, and quantification methods.

Areas covered: This paper provides a comprehensive overview of differentially abundant proteins (DAPs) identified in AP by searching the PubMed/MEDLINE database (2003-2023) and adds significantly to the current theoretical framework.

Expert opinion: DAPs for potentially diagnosing AP based on proteomic identification need to be confirmed by multi-center studies that include larger samples. The discovery of DAPs in various organs at different AP stages via proteomic technologies is essential better to understand the pathophysiology of AP-related multiple organ dysfunction syndrome. Regarding the translational research of AP, novel approaches like single-cell proteomics and imaging using mass spectrometry may be used as soon as they become available.

查看原文本刊更多论文

蛋白质组学在急性胰腺炎中的作用：新旧知识。

简介在确诊为急性胰腺炎（AP）的患者中，约有 20% 的人可能会发展为重症急性胰腺炎（SAP），可能导致 15% 至 35% 的死亡率。目前迫切需要彻底了解不同病因导致的 SAP 的分子表型。通过不断改进分离、标记和定量方法，一些创新的蛋白质组学方法已被应用于有关 AP 的转化研究领域：本文通过检索 PubMed/MEDLINE 数据库（2003-2023 年），全面概述了在 AP 中发现的差异丰度蛋白（DAPs），为当前的理论框架增添了重要内容：专家观点：基于蛋白质组鉴定而可能诊断 AP 的 DAPs 需要通过包含更多样本的多中心研究来证实。通过蛋白质组学技术在AP不同阶段的不同器官中发现DAPs，对于更好地理解AP相关多器官功能障碍综合征的病理生理学至关重要。在 AP 的转化研究方面，单细胞蛋白质组学和质谱成像等新方法一旦问世，就会立即得到应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.