Cryogen-free 400-MHz nuclear magnetic resonance spectrometer as a versatile tool for pharmaceutical process analytical technology

IF 1.9 3区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Maria Victoria Silva Elipe, Ikenna Edward Ndukwe, James I. Murray
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Abstract

The discovery of new ceramic materials containing Ba-La-Cu oxides in 1986 that exhibited superconducting properties at high temperatures in the range of 35 K or higher, recognized with the Nobel Prize in Physics in 1987, opened a new world of opportunities for nuclear magnetic resonance (NMRs) and magnetic resonance imaging (MRIs) to move away from liquid cryogens. This discovery expands the application of high temperature superconducting (HTS) materials to fields beyond the chemical and medical industries, including electrical power grids, energy, and aerospace. The prototype 400-MHz cryofree HTS NMR spectrometer installed at Amgen's chemistry laboratory has been vital for a variety of applications such as structure analysis, reaction monitoring, and CASE-3D studies with RDCs. The spectrometer has been integrated with Amgen's chemistry and analytical workflows, providing pipeline project support in tandem with other Kinetic Analysis Platform technologies. The 400-MHz cryofree HTS NMR spectrometer, as the name implies, does not require liquid cryogens refills and has smaller footprint that facilitates installation into a chemistry laboratory fume hood, sharing the hood with a process chemistry reactor. Our evaluation of its performance for structural analysis with CASE-3D protocol and for reaction monitoring of Amgen's pipeline chemistry was successful. We envision that the HTS magnets would become part of the standard NMR and MRI spectrometers in the future. We believe that while the technology is being developed, there is room for all magnet options, including HTS, low temperature superconducting (LTS) magnets, and low field benchtop NMRs with permanent magnets, where utilization will be dependent on application type and costs.

Abstract Image

Abstract Image

作为制药过程分析技术多功能工具的无低温 400-MHz 核磁共振光谱仪。
1986 年,人们发现了含有钡-镭-铜氧化物的新型陶瓷材料,这种材料在 35 K 或更高的高温下具有超导特性,并于 1987 年获得诺贝尔物理学奖。这一发现将高温超导(HTS)材料的应用扩展到化学和医疗行业以外的领域,包括电网、能源和航空航天。安装在安进公司化学实验室的 400-MHz 无低温 HTS NMR 光谱仪原型对于结构分析、反应监测和使用 RDC 进行 CASE-3D 研究等各种应用至关重要。该光谱仪已与安进公司的化学和分析工作流程集成,与其他动力学分析平台技术一起为流水线项目提供支持。400-MHz 无低温 HTS NMR 光谱仪,顾名思义,不需要补充液态制冷剂,占地面积较小,便于安装在化学实验室通风橱中,与工艺化学反应器共用通风橱。我们成功评估了它在使用 CASE-3D 协议进行结构分析和安进公司管道化学反应监测方面的性能。我们设想 HTS 磁体将来会成为标准核磁共振和磁共振成像光谱仪的一部分。我们相信,在开发这项技术的同时,所有磁体选项都有发展空间,包括 HTS、低温超导 (LTS) 磁体和使用永久磁铁的低磁场台式 NMR,其使用将取决于应用类型和成本。
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来源期刊
CiteScore
4.70
自引率
10.00%
发文量
99
审稿时长
1 months
期刊介绍: MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.
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