Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021

IF 4.5 3区医学 Q1 MICROBIOLOGY

International Journal of Medical Microbiology Pub Date : 2024-02-16 DOI:10.1016/j.ijmm.2024.151614

Johanna Kessel , Anna-Catharina Rossaert , Tilman Lingscheid , Jan Grothe , Thomas Harrer , Christoph Wyen , Daniela Tominski , T. Bollinger , Anna Katharina Kehr , Sven Kalbitz , Christian Hoffmann , Oliver Cornely , Uwe Koppe , Christoph Stephan , Volker Rickerts

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引用次数: 0

Abstract

Cryptococcosis is the most prevalent fungal infection of the central nervous system worldwide. We performed a retrospective multicenter cohort study to gain insights into the epidemiology of cryptococcosis in Germany. We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.

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德国隐球菌病后的存活率：对 2004 年至 2021 年期间确诊患者的多中心队列回顾性研究

隐球菌病是全球最流行的中枢神经系统真菌感染。我们进行了一项回顾性多中心队列研究，以深入了解隐球菌病在德国的流行病学。我们描述了诊断测试的使用、临床管理和患者预后。我们共纳入了 64 名有潜在艾滋病病毒感染（55%）或其他倾向的患者。通过 MLST 进行分子分型，在 42 个分型分离物中发现了 20 个序列类型。在确诊后的头两个月中，有 14% 的患者出现了死亡结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Medical Microbiology 医学-病毒学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

45 days

期刊介绍： Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.