Predictors of efficacy of ultrasound-guided intra-articular glucocorticoid injection in knee osteoarthritis: A prospective study.

IF 1.4 4区 医学 Q3 RHEUMATOLOGY
ARP Rheumatology Pub Date : 2024-07-01 DOI:10.63032/NJOL3215
Samy Slimani, Amel Aissoug, Souhila Aouidane, Nacif Eddine Ghodbane, Aicha Ladjouze-Rezig
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Abstract

Background: Intra-articular glucocorticoid injection (IAGI) is widely used for treatment of knee osteoarthritis (OA) flares. Response rates are generally around 70%. Several studies have tried to identify predictors of good response, but response to ultrasound (US)-guided injection has not yet been investigated. This study aimed to identify the predictors of response to IAGI performed under US guidance in patients with primary knee OA.

Materials and methods: A total of 116 patients (116 knees) presenting with unilateral or bilateral primary knee OA were enrolled for this prospective single-center study. All were aged >40 years and met the American College of Rheumatology (ACR) criteria for knee OA. Demographic, clinical, laboratory, and imaging data were collected, injection was performed using US guidance, and tolerance was assessed. The primary efficacy endpoint was ≥40% reduction in total WOMAC score (WOMAC40). Univariate and multivariate logistic regression analyses were conducted to identify the predictors of response.

Results: The mean age of the patients was 64.2 ± 9.4 years and mean BMI was 29.9 ± 3.8 kg/m2. Total WOMAC40 response rate was 61.2%. In multivariate analysis, the independent predictors of response were BMI.

膝关节骨性关节炎超声引导下关节内注射糖皮质激素疗效的预测因素:一项前瞻性研究
背景:关节内注射糖皮质激素(IAGI)被广泛用于治疗膝关节骨性关节炎(OA)复发。反应率一般在 70% 左右。有几项研究试图确定良好反应的预测因素,但尚未对超声(US)引导注射的反应进行调查。本研究旨在确定原发性膝关节 OA 患者在 US 引导下进行 IAGI 反应的预测因素:这项前瞻性单中心研究共招募了 116 名单侧或双侧原发性膝关节 OA 患者(116 个膝关节)。所有患者的年龄均大于 40 岁,并符合美国风湿病学会(ACR)的膝关节 OA 标准。研究人员收集了人口统计学、临床、实验室和影像学数据,在 US 引导下进行了注射,并评估了耐受性。主要疗效终点是 WOMAC 总分(WOMAC40)降低≥40%。为确定反应的预测因素,进行了单变量和多变量逻辑回归分析:患者的平均年龄为 64.2 ± 9.4 岁,平均体重指数为 29.9 ± 3.8 kg/m2。WOMAC40总反应率为61.2%。在多变量分析中,预测反应的独立因素是体重指数(BMI)。
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