Acute effect of intragastric ethanol administration on plasma levels of stress hormones.

A B Thiagarajan, I N Mefford, R L Eskay
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引用次数: 6

Abstract

We have previously demonstrated that single-dose ethanol administration enhanced plasma levels of ACTH, beta-endorphin, corticosterone (CS) and catecholamines. Since the secretion of proopiomelanocortin-derived peptides (e.g., ACTH, beta-endorphin) can be influenced by catecholamines and vasopressin in addition to the primary physiological regulator, corticotrophin-releasing hormone, we have attempted to determine whether or not the ethanol-induced activation of the hypothalamic-pituitary-adrenal axis (HPAA) could in part be mediated via either epinephrine or vasopressin (AVP) secretion. The selective neutralization of AVP through the administration of AVP antiserum failed to block the ethanol-induced secretion of either ACTH or CS. In addition, adrenal demedullation did not significantly attenuate the ethanol-induced increase of ACTH and CS. It would appear that neither adrenal medulla-derived epinephrine nor median eminence-derived AVP mediates ethanol's activation of the HPAA.

急性灌胃乙醇对应激激素血浆水平的影响。
我们之前已经证明单剂量乙醇可以提高血浆ACTH、-内啡肽、皮质酮(CS)和儿茶酚胺的水平。由于除主要生理调节剂促肾上腺皮质激素释放激素外,促肾上腺皮质激素衍生肽(如ACTH、β -内啡肽)的分泌还可受到儿茶酚胺和抗利尿激素的影响,因此我们试图确定乙醇诱导的下丘脑-垂体-肾上腺轴(HPAA)的激活是否可以部分通过肾上腺素或抗利尿激素(AVP)分泌介导。通过给药AVP抗血清选择性中和AVP不能阻断乙醇诱导的ACTH或CS分泌。此外,肾上腺脱髓没有显著减弱乙醇诱导的ACTH和CS升高。看来肾上腺髓质来源的肾上腺素和正中隆起来源的AVP都不能介导乙醇对HPAA的激活。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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