Pharmacological Approaches to Nonalcoholic Fatty Liver Disease: Current and Future Therapies

Q3 Medicine

Diabetes Spectrum Pub Date : 2024-02-01 DOI:10.2337/dsi23-0012

I. Genua, Kenneth Cusi

引用次数: 3

Abstract

Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), can promote the development of cirrhosis, hepatocellular carcinoma, cardiovascular disease, and type 2 diabetes. Similarly, type 2 diabetes confers the greatest risk for the development of NASH, especially when associated with obesity. Although lifestyle changes are critical to success, early implementation of pharmacological treatments for obesity and type 2 diabetes are essential to treat NASH and avoid disease progression. This article reviews current guidance regarding the use of pharmacological agents such as pioglitazone, glucagon-like peptide 1 receptor agonists, and sodium–glucose cotransporter 2 inhibitors in the setting of NAFLD and NASH. It also reviews the latest information on new drugs currently being investigated for the treatment of NASH.

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非酒精性脂肪肝的药物治疗方法：当前和未来的疗法

非酒精性脂肪肝（NAFLD）及其更严重的非酒精性脂肪性肝炎（NASH）可诱发肝硬化、肝细胞癌、心血管疾病和 2 型糖尿病。同样，2 型糖尿病也会带来罹患 NASH 的最大风险，尤其是在肥胖的情况下。虽然改变生活方式是成功的关键，但尽早对肥胖和 2 型糖尿病实施药物治疗对于治疗 NASH 和避免疾病进展至关重要。本文回顾了在非酒精性脂肪肝和 NASH 的情况下使用吡格列酮、胰高血糖素样肽 1 受体激动剂和钠-葡萄糖共转运体 2 抑制剂等药理药物的现行指南。报告还回顾了目前正在研究用于治疗非酒精性脂肪肝的新药的最新信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Spectrum Medicine-Internal Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： The mission of Diabetes Spectrum: From Research to Practice is to assist health care professionals in the development of strategies to individualize treatment and diabetes self-management education for improved quality of life and diabetes control. These goals are achieved by presenting review as well as original, peer-reviewed articles on topics in clinical diabetes management, professional and patient education, nutrition, behavioral science and counseling, educational program development, and advocacy. In each issue, the FROM RESEARCH TO PRACTICE section explores, in depth, a diabetes care topic and provides practical application of current research findings.