Nanoemulsions Containing Mucuna pruriens (L.) DC. Seed Extract for Cosmetic Applications

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cosmetics Pub Date : 2024-02-12 DOI:10.3390/cosmetics11010029

Suwaporn Chookiat, Tinnakorn Theansungnoen, Kanokwan Kiattisin, Aekkhaluck Intharuksa

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引用次数: 0

Abstract

Mucuna pruriens is a medicinal plant whose seeds have various types of pharmacological activities and are used in many traditional medicines. The aim of this study was to evaluate the phytochemicals as well as the anti-aging, antioxidant, and moisturizing properties of seed extracts of M. pruriens var. pruriens and M. pruriens var. utilis. In addition, the best extract was selected for the development of nanoemulsions. M. pruriens var. utilis had the highest total phenolic and total flavonoid contents. It had good antioxidant activity (the IC50 of DPPH was 4.87 µg/mL, the FRAP value was 1.63 mg of FeSO4/mg of extract, and the percentage of lipid peroxidation was 80.19%) and anti-aging activity (the percentages of inhibition of hyaluronidase, collagenase, and elastase were 26.41%, 51.16%, and 22.78%, respectively). The occlusive factor was 46.12 ± 1.72. Therefore, M. pruriens var. utilis seed extract was selected for the preparation of nanoemulsions. The results showed that the size, PDI, and zeta potential of nanoemulsions containing M. pruriens var. utilis seed extract at day 30 did not significantly differ from those at day 0. In addition, the %EE was 63.46%. A study of skin permeation showed that the retention in the membrane after six hours of skin permeation study was 44.19%. Therefore, nanoemulsions containing M. pruriens var. utilis seed extract have good potential for further use in cosmetic applications.

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含白茅（L. DC.种子提取物的纳米乳液

毛果芸香科植物毛果芸香属药用植物，其种子具有多种药理活性，被用于多种传统药物中。本研究的目的是评估白豆蔻种子提取物的植物化学成分以及抗衰老、抗氧化和保湿特性。此外，还选择了最佳提取物用于纳米乳剂的开发。M. pruriens var. utilis 的总酚和总黄酮含量最高。它具有良好的抗氧化活性（DPPH 的 IC50 值为 4.87 µg/mL，FRAP 值为 1.63 mg FeSO4/mg，脂质过氧化百分比为 80.19%）和抗衰老活性（对透明质酸酶、胶原酶和弹性蛋白酶的抑制百分比分别为 26.41%、51.16% 和 22.78%）。闭塞因子为 46.12 ± 1.72。因此，选择 M. pruriens var.结果表明，含有欧鼠李种子提取物的纳米乳液在第 30 天时的粒度、PDI 和 zeta 电位与第 0 天时没有显著差异。皮肤渗透研究表明，经过六小时的皮肤渗透研究后，在膜中的保留率为 44.19%。因此，含有欧罂粟种子提取物的纳米乳液具有在化妆品中进一步应用的良好潜力。

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来源期刊

Cosmetics Medicine-Surgery

CiteScore

5.20

自引率

12.10%

发文量

108

审稿时长

8 weeks