Comparative studies on haemato-biochemical changes following pre-emptive analgesia with tramadol, pentazocine lactate and meloxicam inpain management of canine ovariohysterectomy

The Indian Journal of Animal Sciences Pub Date : 2024-02-12 DOI:10.56093/ijans.v94i2.132408

C. S N, B. Saikia, B. Konwar, H. Bayan, T. R. Devi, Champak Jyoti Das, H. Zorinpuii

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Abstract

The present study was conducted to evaluate the effects of tramadol, pentazocine lactate and meloxicam as pre- emptive analgesics in dogs premedicated with glycopyrrolate, inducted with propofol and maintained with propofol continuous rate infusion (CRI) for certain haematological and biochemical parameters. The animals were randomly divided into three equal groups,viz. Group-T, Group-P and Group-M comprising six animals in each group and all the animals were premedicated with glycopyrrolate. After 10 min of pre-anaesthetic administration, pre-emptive analgesia was given. Blood was collected from cephalic or saphenous vein at intervals 0 (baseline) min before premedication, thereafter at 10 min, 30 min, 1 h, 2 h and 3 h after pre-emptive analgesic administration and haemato- biochemical parameters were recorded. Hb, PCV and TEC were significantly decreased at 30 min and 1 h interval in all the three groups. TLC and glucose concentration were significantly higher in group-M as compared to group-T and group-P at different time intervals. GGT level increased significantly at 30 min in all the three groups. CRP concentration was significantly higher in group-M as compared to group-T. Total protein was significantly decreased at 1 h interval in group-T and group-P, but in group-M such finding was noticed at 2 h interval. Cortisol was significantly lower in group-T in entire study period. The alterations in physiological and haematological parameters caused by tramadol, pentazocine lactate and meloxicam were found to be minimal and within the physiological limits. Tramadol produced less significant rise in CRP and cortisol concentrations which indicated better pain management. Based on the findings of the present study, it is concluded that tramadol is more effective as compared to pentazocine lactate and meloxicam in the management of post-operative pain due to canine ovariohysterectomy.

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在犬卵巢切除术疼痛治疗中使用曲马多、乳酸喷他佐辛和美洛昔康进行预先镇痛后血液生化变化的比较研究

本研究旨在评估曲马多、乳酸喷他佐辛和美洛昔康作为空腹前镇痛药对预先服用甘草酸苷、使用异丙酚诱导和使用异丙酚持续输注（CRI）的狗的某些血液学和生化参数的影响。动物被随机分为三个等量组，即 T 组、P 组和 M 组，每组六只，所有动物均使用甘珀酸进行麻醉前处理。麻醉前给药 10 分钟后，给予镇痛。在预麻醉前 0 分钟（基线），之后的 10 分钟、30 分钟、1 小时、2 小时和 3 小时分别从头静脉或隐静脉采血，记录血液生化指标。在间隔 30 分钟和 1 小时时，所有三组的 Hb、PCV 和 TEC 都明显下降。与 T 组和 P 组相比，M 组在不同时间间隔内的 TLC 和葡萄糖浓度明显升高。三组的 GGT 水平在 30 分钟时均明显升高。与 T 组相比，M 组的 CRP 浓度明显升高。在间隔 1 小时时，T 组和 P 组的总蛋白明显下降，但在间隔 2 小时时，M 组的总蛋白也明显下降。在整个研究期间，T 组的皮质醇明显降低。研究发现，曲马多、乳酸喷他佐辛和美洛昔康对生理和血液学参数的改变极小，且在生理范围内。曲马多引起的 CRP 和皮质醇浓度上升不明显，这表明曲马多能更好地控制疼痛。根据本研究的结论，曲马多在治疗犬卵巢切除术后疼痛方面比乳酸喷他佐辛和美洛昔康更有效。

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The Indian Journal of Animal Sciences

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