Mathematical Modelling and Computational Dynamics of the impact of Quasi-Lockdown Policy in Control of COVID-19 in Akwa Ibom State, Nigeria

E. E. Joshua, E. T. Akpan, Udoinyang Godwin Inyang
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Abstract

Determining the impact of a local control strategy, implemented to curtail the spread of COVID-19 has become obligatory to enable policy makers to combat the so-called long covid. This research used a deterministic SEIAHR-model, incorporating a logistic function to investigate the effect of quasi-lockdown policy during reemergence of corona virus pandemic. The notion of uniform convergence and fixed point theory were used to establish positive invariant region, ultimate boundedness, and existence of unique solution of the model. Nonlinear dynamical behaviours of the model such as stability and oscillating flows occurred at the disease free, and endemic equilibrium points. Using centre manifold theory, a trans-critical bifurcation with hysteresis effect were established, when quasi-lockdown policy was used as a control parameter in the model. A forward sensitivity analysis was conducted to unfold parameters that contributed significantly towards the spread and control of the infection. These parameters were estimated and fitted using least square technique, comparative to the observed real datasets adapted from the Nigeria Centre for Disease Control (NCDC). The polynomial regression model fitted the observed datasets with an average coefficient of determination given as R2 = 0.94. Simulations in form of phase space diagrams were used to validate the theoretic results. Epidemiologically, the model demonstrated that quasi-lockdown policy was necessarily a strategic policy to curb the spread of the infection, but not sufficient to eradicate the disease as the disease persisted endemically. It was shown that the basic reproduction number of the infection was within the critical threshold (R0 \(\le\) 1), when the lockdown policy was enforced strictly, but otherwise on relaxation of the lockdown policy (R0 \(\ge\) 1) Thus a relaxation of the quasi-lockdown policy leads to increase in susceptibility of the populace as the infection risk ratio increases in the model. Similarly, the model predicted that a pre-mature lifting of the lockdown policy could have led to high infectivity on the susceptible class and disastrous to healthy living of the citizens.
尼日利亚阿夸伊博姆州准封锁政策对控制 COVID-19 影响的数学建模和计算动力学
确定为遏制 COVID-19 传播而实施的地方控制策略的影响,已成为政策制定者对抗所谓的 "长线科维 "的必要条件。本研究使用了一个确定性的 SEIAHR 模型,其中包含了一个 logistic 函数,以研究在日冕病毒再次流行期间准封锁政策的效果。利用均匀收敛概念和定点理论建立了模型的正不变区域、终极有界性和唯一解的存在性。模型的非线性动力学行为,如稳定性和振荡流,出现在无疾病平衡点和流行平衡点。利用中心流形理论,在模型中使用准封锁政策作为控制参数时,建立了具有滞后效应的跨临界分岔。进行了前向敏感性分析,以确定对感染的传播和控制有重大影响的参数。使用最小平方技术对这些参数进行了估计和拟合,并与从尼日利亚疾病控制中心(NCDC)获得的实际数据集进行了比较。多项式回归模型与观察到的数据集相吻合,平均判定系数为 R2 = 0.94。以相空间图的形式进行的模拟验证了理论结果。从流行病学角度看,该模型表明,准封锁政策必然是一种遏制感染传播的战略政策,但不足以根除疾病,因为疾病仍在地方流行。结果表明,当严格执行封锁政策时,感染的基本繁殖数量在临界阈值(R0 \(\ge\)1)之内,否则在放松封锁政策时(R0 \(\ge\)1),因此,随着模型中感染风险比的增加,准封锁政策的放松会导致人口易感性的增加。同样,模型预测,过早解除封锁政策可能会导致易感人群的高感染率,并对公民的健康生活造成灾难性影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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