Comparison and evaluation of efficacy of tacrolimus 0.1% and triamcinolone acetonide 0.1% in the management of symptomatic oral lichen planus.

Saba Parveen Soomro, Manorma Maheshwari, Marhaba Shaikh, Wajid Ali Rajper, Shafqat Hussain Khuwaja, Arjeet Kumar, Waqas Iqbal
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Abstract

Objective: To evaluate and compare the effectiveness of tacrolimus 0.1% and triamcinolone acetonide 0.1% used topically to treat symptomatic OLP. Study Design: Cross sectional study. Setting: Oral Medicine Isra Dental College Hyderabad. Period: 1st February 2022 to 31st January 2023. Material & Methods: Total 60 clinically diagnosed patients of symptomatic oral lichen planus were included in study, 60 patients were equally divided into two groups as Group A and group B. Thirty patients of OLP group A were treated with Tracolimus 0.1% four times per day for four weeks and patients of group B were treated with Triamcinolone Acetonide 0.1% ointment. Results: Total 60 symptomatic OLP patients were categorized into to equal groups A and B group. OLP was commonly found in female as compare to male, VAS score and clinical score was calculated before and after the treatment, the mean VAS score of group A was 9.2 (SD±2.07) and group B was 8.9 (SD±2.07) before the treatment. While VAS score of group A 1.9 (SD±1.18) which was treated with tacrolimus (0.1%) and group B score was 2.3 (SD±1.49) which was treated with triamcinolone (0.1%) after the treatment. The mean clinical score of group A was 4.2 (SD±1.14) and 4.6 (SD±1.28) in group B before treatment. Mean clinical score was 1.8 (SD±0.87) in group A and 2.4 (SD±0.9) in group-B after treatment. Conclusion: Study reported Tacrolimus 0.1% is more effective then triamcinolone 0.1% for the treatment of symptomatic OLP however there was no reoccurrence found.
他克莫司 0.1%与曲安奈德 0.1%在治疗症状性口腔扁平苔藓中的疗效比较与评估。
目的评估并比较他克莫司0.1%和曲安奈德0.1%用于局部治疗症状性OLP的疗效。研究设计:横断面研究。研究地点海得拉巴伊斯拉牙科学院口腔医学系。时间:2022 年 2 月 1 日至 1 月 31 日2022 年 2 月 1 日至 2023 年 1 月 31 日。材料与方法A组30名OLP患者接受0.1%曲克莫司治疗,每天4次,持续4周;B组患者接受0.1%曲安奈德软膏治疗。结果60名有症状的OLP患者被分为A组和B组。计算治疗前后的 VAS 评分和临床评分,治疗前 A 组的平均 VAS 评分为 9.2(SD±2.07)分,B 组为 8.9(SD±2.07)分。治疗后,使用他克莫司(0.1%)治疗的 A 组 VAS 评分为 1.9(SD±1.18),使用曲安奈德(0.1%)治疗的 B 组 VAS 评分为 2.3(SD±1.49)。治疗前,A 组的平均临床评分为 4.2(SD±1.14)分,B 组为 4.6(SD±1.28)分。治疗后,A 组的平均临床评分为 1.8(SD±0.87)分,B 组为 2.4(SD±0.9)分。结论研究报告显示,在治疗无症状OLP方面,他克莫司0.1%比曲安奈德0.1%更有效,但没有发现复发现象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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