Breast lymphoma mimicking benign breast lesions: A diagnostic challenge

Abstract

NHL Primary of the breast is rare accounting 0.1% of the total malignancy. DLBCL is the most common histology for Primary NHL breast. It presentation is similar to carcinoma breast so biopsy followed by IHC is only method to differentiate between both. Due to rarity of the tumor there is lack of literature on proper diagnosis and treatment. RCHOP is the chemotherapy regime used and radiotherapy role is not clear. Some studies suggest role of CNS irradiation in high risk patient because of high chances of CNS spread in advance stage patient. In this paper we aim to highlight the diagnostic difficulties we faced and the treatment we followed. Here we bring to the knowledge of the reader about the review over diagnosis, clinical feature and treatment of NHL breast along side with two clinical cases to enhance clinical interest of the reviewer.