Efficiency of ozone (O3) therapy on experimental acidic skin burns in rats

Aslan Nevzat Emre, Hanifi Erol, Esra Balcıoğlu, Yalçin Betül
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Abstract

In this study, it was aimed to investigate the efficacy of O3 therapy in experimentally induced HF skin burns in rats. A total of 20 healthy male Wistar Albino rats (weighing 250-300 g, aged 16 weeks) were used as the material of the study. They were divided into two groups (as experimental and control groups) of 10 rats which were housed individually and fed ad libitum. Hydrofluoric acid (HF) skin burns were induced in all animals. The ozonized (20 µg O3/mL) liquid vaseline was applied topically for seven days to the experiment group as well as parallelly, a saline solution was applied to the control group. In the histopathologic evaluation, inflammation, vascularization, epithelial regeneration and fibrosis were evaluated. The epithelial proliferation and collagenization were higher and statistically significant in the experimental group, while the infiltration was higher and statistically significant in the control group. As a result of this study, it was observed that ozone plays an important role in the tissue repair process in chemical burns. The increase of fibroblast activation and re-epithelization in the experimental group demonstrated that ozone therapy could be suggested as first aid in HF skin burns. It was concluded that more studies on ozone are needed to shed light on the subject.
臭氧(O3)疗法对大鼠实验性酸性皮肤烧伤的疗效
本研究旨在探讨臭氧疗法对实验性高频皮肤烧伤大鼠的疗效。研究以 20 只健康雄性 Wistar Albino 大鼠(体重 250-300 克,年龄 16 周)为材料。它们被分为两组(实验组和对照组),每组 10 只,单独饲养,自由进食。所有动物均被氢氟酸(HF)灼伤皮肤。实验组大鼠局部涂抹臭氧(20 µg O3/mL)液体凡士林七天,对照组大鼠同时涂抹生理盐水。在组织病理学评估中,对炎症、血管生成、上皮再生和纤维化进行了评估。实验组的上皮增生和胶原化程度较高,且具有统计学意义,而对照组的浸润程度较高,且具有统计学意义。研究结果表明,臭氧在化学烧伤的组织修复过程中发挥着重要作用。实验组成纤维细胞活化和重新上皮的增加表明,臭氧疗法可作为高频皮肤烧伤的急救方法。结论是需要对臭氧进行更多的研究,以阐明这一主题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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