Drug Repositioning for Ovarian Cancer Treatment: An Update

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Anti-cancer agents in medicinal chemistry Pub Date : 2024-02-16 DOI:10.2174/0118715206282904240122063914

Maria Maddalena Cavalluzzi, Maurizio Viale, Natalie Paola Rotondo, Valeria Ferraro, Giovanni Lentini

引用次数: 0

Abstract

: Ovarian cancer (OC) is one of the most prevalent malignancies in female reproductive organs, and its 5-year survival is below 45%. Despite the advances in surgical and chemotherapeutic options, OC treatment is still a challenge, and new anticancer agents are urgently needed. Drug repositioning has gained significant attention in drug discovery, representing a smart way to identify new clinical applications for drugs whose human safety and pharmacokinetics have already been established, with great time and cost savings in pharmaceutical development endeavors. This review offers an update on the most promising drugs repurposable for OC treatment and/or prevention.

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卵巢癌治疗药物的重新定位：最新进展

:卵巢癌（OC）是女性生殖器官中最常见的恶性肿瘤之一，其 5 年生存率低于 45%。尽管在手术和化疗方面取得了进展，但卵巢癌的治疗仍然是一项挑战，迫切需要新的抗癌药物。药物重新定位在新药研发中备受关注，它是为人体安全性和药代动力学已经确定的药物寻找新的临床应用领域的明智之举，大大节省了药物研发的时间和成本。本综述介绍了可重新用于治疗和/或预防 OC 的最有前途药物的最新情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL

CiteScore

5.10

自引率

3.60%

发文量

323

审稿时长

4-8 weeks

期刊介绍： Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.