{"title":"An Insight into the Approach Taken to Appurtenances Disorders Linked to Mitochondria","authors":"El Bethel Lalthavel Hmar, Sujata Paul, Rofiqul Islam, Hemanta Kumar Sharma","doi":"10.1134/s1062359023604962","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Mitochondria are essential components of bioenergetic and biosynthetic pathways and are capable of making quick adjustments to accommodate the cell’s changing metabolic requirements. Mitochondria are dynamic organelles that conduct a variety of functions, including adenosine triphosphate synthesis, calcium homeostasis management, apoptosis, and population maintenance via fission and fusion. Mitochondrial malfunction manifested as oxidative stress and mutations can contribute to the aetiology of a variety of catastrophic disorders, including neurological disease, neuromuscular disease, ischemia-reperfusion damage, cancer, and the ageing process. This mitochondrial dysfunction prompted a thorough search for novel strategies that utilize critical facets of mitochondrial biogenesis, dynamics, mitophagy, redox metabolism, and the unfolded protein response to restore mitochondrial function. In the literature, from cardiovascular to neurodegenerative illnesses, targeting mitochondria as a therapeutic intervention to avoid cellular damage or cell death has been mentioned more frequently. For mitochondrial delivery currently, both passive and active targeting has been used. But due to the physical characteristics of mitochondria, passive targeting is challenging. In this review, we explore approaches and techniques for directing drugs and genetic materials to the mitochondria for mitochondrial dysfunction in the pathophysiology of various disorders associated with mitochondria.</p>","PeriodicalId":55366,"journal":{"name":"Biology Bulletin","volume":"75 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology Bulletin","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s1062359023604962","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Mitochondria are essential components of bioenergetic and biosynthetic pathways and are capable of making quick adjustments to accommodate the cell’s changing metabolic requirements. Mitochondria are dynamic organelles that conduct a variety of functions, including adenosine triphosphate synthesis, calcium homeostasis management, apoptosis, and population maintenance via fission and fusion. Mitochondrial malfunction manifested as oxidative stress and mutations can contribute to the aetiology of a variety of catastrophic disorders, including neurological disease, neuromuscular disease, ischemia-reperfusion damage, cancer, and the ageing process. This mitochondrial dysfunction prompted a thorough search for novel strategies that utilize critical facets of mitochondrial biogenesis, dynamics, mitophagy, redox metabolism, and the unfolded protein response to restore mitochondrial function. In the literature, from cardiovascular to neurodegenerative illnesses, targeting mitochondria as a therapeutic intervention to avoid cellular damage or cell death has been mentioned more frequently. For mitochondrial delivery currently, both passive and active targeting has been used. But due to the physical characteristics of mitochondria, passive targeting is challenging. In this review, we explore approaches and techniques for directing drugs and genetic materials to the mitochondria for mitochondrial dysfunction in the pathophysiology of various disorders associated with mitochondria.
期刊介绍：
Biology Bulletin (Izvestiya Rossiiskoi Akademii Nauk – Seriya Biologicheskaya) is an interdisciplinary journal of general biology. It focuses on fundamental studies in the fields of cell biology, biochemistry, zoology, botany, physiology, and ecology. This journal publishes current materials of experimental studies and surveys on current problems in general biology. It also publishes information on scientific conferences and new books in the fields of general biology.
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