Lamellar liquid crystals formed from sucrose ester and Brij97 solutions for curcumin delivery

IF 1.2 4区工程技术 Q4 CHEMISTRY, APPLIED

Tenside Surfactants Detergents Pub Date : 2024-02-12 DOI:10.1515/tsd-2023-2569

Fumin Guo, Xuepeng Li, Jun Fan, Xuebin Ma, Zhongni Wang

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引用次数: 0

Abstract

In this paper, the lamellar liquid crystals formed in S1570-Brij97/isopropyl myristate/PEG400 aqueous system were prepared at 37 °C. The effects of PEG400 and curcumin on the S1570-Brij97 lyotropic liquid crystal systems were studied by phase diagram, polarized optical microscopy, small angle X-ray scattering, and rheology. The prepared lamellar liquid crystals show stable structures at 37 °C. The encapsulation of curcumin improves the structural stability of the lamellar liquid crystals, which can be confirmed by their higher η γ=0.013 and σ y values, suggesting that the S1570-Brij97 lamellar liquid crystals are good carriers for curcumin. In addition, the prepared lamellar liquid crystals can effectively protect curcumin from decomposition, and curcumin can be released slowly in the liquid crystals. Therefore, based on the structural stability, protective effect on curcumin, and slow-release behavior, the constructed S1570-Brij97 lamellar liquid crystals have good potential for drug delivery.

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蔗糖酯和 Brij97 溶液形成的层状液晶用于姜黄素的输送

本文在 37 °C下制备了S1570-Brij97/肉豆蔻酸异丙酯/PEG400水溶液体系中形成的片状液晶。通过相图、偏振光学显微镜、小角 X 射线散射和流变学研究了 PEG400 和姜黄素对 S1570-Brij97 各向同性液晶体系的影响。所制备的层状液晶在 37 ℃ 下显示出稳定的结构。姜黄素的封装提高了层状液晶的结构稳定性，这可以从其较高的η γ=0.013 和 σ y 值得到证实，表明 S1570-Brij97 层状液晶是姜黄素的良好载体。此外，所制备的层状液晶能有效保护姜黄素不被分解，姜黄素也能在液晶中缓慢释放。因此，基于结构稳定性、对姜黄素的保护作用和缓释行为，所构建的 S1570-Brij97 片状液晶具有良好的给药潜力。

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来源期刊

Tenside Surfactants Detergents 工程技术-工程：化工

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

3.8 months

期刊介绍： Tenside Surfactants Detergents offers the most recent results of research and development in all fields of surfactant chemistry, such as: synthesis, analysis, physicochemical properties, new types of surfactants, progress in production processes, application-related problems and environmental behavior. Since 1964 Tenside Surfactants Detergents offers strictly peer-reviewed, high-quality articles by renowned specialists around the world.