Design of a Low Voltage TCNQ-Pd-Co@NC-Modified Electrode–Based NADH Sensor

IF 2.7 4区化学 Q3 CHEMISTRY, PHYSICAL

Electrocatalysis Pub Date : 2024-02-13 DOI:10.1007/s12678-024-00865-y

Kuldeep Kumar Maurya, Kulveer Singh, Chitra Singh, Manisha Malviya

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Abstract

The present work involves the design and validation of an electrochemical sensor for precise and selective sensing of nicotinamide adenine dinucleotide (NADH). The designed electrochemical sensor consists of TCNQ and Pd-Co@NC nanocomposite–modified electrodes (TCNQ-Pd-Co@NC/CPE). The designed electrode was validated by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy (EIS). The results revealed potent electrocatalytic activity towards NADH oxidation and sensing. Cyclic voltammetry revealed the superior capability of TCNQ-Pd-Co@NC-based carbon paste electrode in electron transfer than TCNQ-Co@NC/CPE and TCNQ/CPE, validating better conductivity of TCNQ-Pd-Co@NC/CPE for NADH sensing. Amperometry study provided a wide linear range of 10 to 250 µM for NADH detection with a low detection limit (LOD) of 5.17 µM and a sensitivity of 21.5 µA mM. EIS study revealed the lowest R_ct value of 12.5 × 10² for TCNQ-Pd-Co@NC/CPE compared to TCNQ-Co@NC/CPE and TCNQ/CPE, demonstrating high electron transfer capability and thus sensitivity towards NADH. Besides this, the modified TCNQ-Pd-Co@NC-based carbon paste electrodes offered exceptional selectivity, reproducibility, and stability over time. Therefore, designed TCNQ-Pd-Co@NC nanocomposite–based carbon paste electrodes can be efficiently used for precise and selective NADH sensing.

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设计低电压 TCNQ-Pd-Co@NC 改性电极式 NADH 传感器

本研究涉及设计和验证一种电化学传感器，用于精确和选择性地检测烟酰胺腺嘌呤二核苷酸（NADH）。所设计的电化学传感器由 TCNQ 和 Pd-Co@NC 纳米复合材料修饰电极（TCNQ-Pd-Co@NC/CPE）组成。循环伏安法、安培计和电化学阻抗谱（EIS）对所设计的电极进行了验证。结果表明，该电极对 NADH 氧化和传感具有很强的电催化活性。循环伏安法显示，与 TCNQ-Co@NC/CPE 和 TCNQ/CPE 相比，基于 TCNQ-Pd-Co@NC 的碳浆电极具有更强的电子传递能力，这也验证了 TCNQ-Pd-Co@NC/CPE 在 NADH 传感方面具有更好的导电性。安培计研究为 NADH 检测提供了 10 至 250 µM 的宽线性范围，低检测限 (LOD) 为 5.17 µM，灵敏度为 21.5 µA mM。EIS 研究显示，与 TCNQ-Co@NC/CPE 和 TCNQ/CPE 相比，TCNQ-Pd-Co@NC/CPE 的 Rct 值最低，为 12.5 × 102，这表明其具有较高的电子传递能力，因此对 NADH 的灵敏度较高。此外，改性的 TCNQ-Pd-Co@NC 碳浆电极还具有优异的选择性、再现性和长期稳定性。因此，所设计的 TCNQ-Pd-Co@NC 纳米复合材料碳浆电极可有效地用于精确和选择性 NADH 传感。

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来源期刊

Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

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