Association of blood cadmium concentration with chronic obstructive pulmonary disease progression: a prospective cohort study

IF 4.7 2区医学 Q1 RESPIRATORY SYSTEM

Respiratory Research Pub Date : 2024-02-17 DOI:10.1186/s12931-024-02726-0

Jing Sun, You-Peng Deng, Juan Xu, Feng-Min Zhu, Qi-Yuan He, Min-Min Tang, Ying Liu, Jin Yang, Hong-Yan Liu, Lin Fu, Hui Zhao

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Abstract

Prior studies in patients with chronic obstructive pulmonary disease (COPD) had indicated a potential correlation between cadmium (Cd) exposure and reduction in lung function. Nevertheless, the influence of Cd exposure on the progression of COPD remained unknown. Exploring the relationship between Cd exposure and the progression of COPD was the aim of this investigation. Stable COPD patients were enrolled. Blood samples were collected and lung function was evaluated. Regular professional follow-ups were conducted through telephone communications, outpatient services, and patients' hospitalization records. Each additional unit of blood Cd was associated with upward trend in acute exacerbation, hospitalization, longer hospital stay, and death within 2 years. Even after adjusting for potential confounding factors, each 1 unit rise in blood Cd still correlated with a rise in the frequencies of acute exacerbation, longer hospital stay, and death. Moreover, COPD patients with less smoking amount, lower lung function and without comorbidities were more vulnerable to Cd-induced disease deterioration. Patients with COPD who have higher blood Cd concentration are susceptible to worse disease progression.

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血液中镉浓度与慢性阻塞性肺病进展的关系：一项前瞻性队列研究

之前对慢性阻塞性肺病（COPD）患者进行的研究表明，镉（Cd）暴露与肺功能下降之间存在潜在的相关性。然而，镉暴露对慢性阻塞性肺病进展的影响仍然未知。本研究旨在探讨镉暴露与慢性阻塞性肺病进展之间的关系。研究人员招募了病情稳定的慢性阻塞性肺病患者。采集血液样本并评估肺功能。通过电话沟通、门诊服务和患者住院记录进行定期专业随访。血镉每增加一个单位，急性加重、住院、住院时间延长和两年内死亡的趋势就会增加。即使在调整了潜在的混杂因素后，血 Cd 每上升 1 个单位仍与急性加重、住院时间延长和死亡的频率上升相关。此外，吸烟量较少、肺功能较低且无合并症的慢性阻塞性肺病患者更容易受到镉引起的病情恶化的影响。血液中镉浓度较高的慢性阻塞性肺病患者的病情更容易恶化。

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来源期刊

Respiratory Research 医学-呼吸系统

自引率

1.70%

发文量

314

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.