Clinical and pathological differences between early- and late-onset colorectal cancer and determinants of one-year all-cause mortality among advanced-stage patients: a retrospective cohort study in Medellín, Colombia

Q3 Medicine
Álvaro Esteban Ruiz Grajales , Manuela María Orozco Puerta , Senshuang Zheng , Geertruida H. de Bock , Juan Camilo Correa Cote , Esteban Castrillón Martínez
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引用次数: 0

Abstract

Objective

To identify the differences between early- (EOCRC) and late-onset colorectal cancer (LOCRC), and to evaluate the determinants of one-year all-cause mortality among advanced-stage patients.

Methods

A retrospective cohort study was carried out. CRC patients ≥ 18 years old were included. Chi-Square test was applied to compare both groups. Uni- and multivariate regressions were performed to evaluate the determinants of one-year all-cause mortality in all advanced-stage patients regardless of age of onset.

Results

A total of 416 patients were enrolled; 53.1 % were female. Ninety cases (21.6 %) had EOCRC and 326 (78.4 %) had LOCRC. EOCRC cases were predominantly sporadic (88.9 %). Histology of carcinoma other than adenocarcinoma (p = 0.044) and rectum tumors (p = 0.039) were more prevalent in EOCRC. LOCRC patients were more likely to have smoking history (p < 0.001) and right colon tumors (p = 0.039). Alcohol consumption history (odds ratio [OR]: 3.375, 95 %CI: 1.022–11.150) and stage IV (OR: 12.632, 95 %CI: 3.506–45.513) were associated with higher one-year all-cause mortality among advanced-stage patients, the opposite was noted with left colon tumors (OR: 0.045, 95 %CI: 0.003–0.588).

Conclusion

EOCRC was predominantly sporadic and had more cases of uncommon histological subtypes and rectal tumors. LOCRC was characterized by a higher prevalence of smoking history. Multivariate regression revealed an association between higher one-year all-cause mortality and alcohol consumption history and stage IV in advanced-stage patients. CRC exhibited differences based on age of onset. The evaluated factors associated with CRC mortality provide valuable insights for healthcare professionals, emphasizing the importance of adequate clinical assessment and early CRC diagnosis.

早期和晚期结直肠癌的临床和病理差异以及晚期患者一年全因死亡率的决定因素:哥伦比亚麦德林的一项回顾性队列研究
目的 找出早期(EOCRC)和晚期(LOCRC)结直肠癌之间的差异,并评估晚期患者一年全因死亡率的决定因素。 方法 开展一项回顾性队列研究。研究纳入了年龄≥ 18 岁的 CRC 患者。采用 Chi-Square 检验对两组患者进行比较。结果共纳入 416 例患者,其中 53.1% 为女性。其中 90 例(21.6%)为 EOCRC,326 例(78.4%)为 LOCRC。EOCRC病例主要为散发性(88.9%)。除腺癌(p = 0.044)和直肠肿瘤(p = 0.039)以外的其他组织学癌在 EOCRC 中更为常见。LOCRC患者更有可能有吸烟史(p < 0.001)和右侧结肠肿瘤(p = 0.039)。在晚期患者中,饮酒史(几率比 [OR]:3.375,95 %CI:1.022-11.150)和 IV 期(OR:12.632,95 %CI:3.506-45.513)与较高的一年全因死亡率相关,而左结肠肿瘤则相反(OR:0.结论EOCRC 以散发性为主,不常见的组织学亚型和直肠肿瘤病例较多。LOCRC的特点是吸烟史发生率较高。多变量回归显示,晚期患者较高的一年全因死亡率与饮酒史和 IV 期之间存在关联。根据发病年龄的不同,CRC 也存在差异。所评估的与 CRC 死亡率相关的因素为医护人员提供了宝贵的见解,强调了充分的临床评估和早期诊断 CRC 的重要性。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
148
审稿时长
56 days
期刊介绍: Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.
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