Equol production capability and family history as risk factors for hand osteoarthritis in menopausal and postmenopausal women. Cross-sectional study

IF 1.5 4区 医学 Q3 ORTHOPEDICS
Yuichi Hirase, Arisa Okubo
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引用次数: 0

Abstract

Background

Hand disorders are common in menopausal women. Equol is a soy metabolite produced in humans and its production level differs among individuals. The purpose of this research is to investigate the correlative relationship between variables indicating equol production levels and the occurrence of hand disorders in menopausal and postmenopausal women.

Methods

Female subjects were divided into two groups: women 45–70 years of age with hand osteoarthritis (patient group) and women in the same age range without hand osteoarthritis (control group). The equol production level of each subject was estimated by measuring her urine equol concentration. We also surveyed the subjects’ family histories of osteoarthritis.

Results

Equol levels in the patient group were significantly lower than those in the control group (p < 0.05). This difference was most apparent for women in their 50s. Individuals with family histories of Heberden's and Bouchard's nodes were found to be 48.1 times more likely to develop these conditions than individuals in the control group.

Conclusions

Women with early menopausal hand symptoms (i.e., stiff and arthritic hands) often develop hand osteoarthritis during their late menopausal and postmenopausal periods, which may cause their QoL to significantly deteriorate. Although a link between the probability of women developing hand osteoarthritis and their clinical backgrounds (i.e., family history) had been suspected, it had not been thoroughly investigated. Our survey of women with and without Heberden's nodes and Bouchard's nodes found a significant correlation between the likelihood of women developing osteoarthritis and a family history of this disease. We also found a significant correlation between the likelihood of women developing hand osteoarthritis and their equol production levels. These results indicate that women with family histories of finger osteoarthritis and low equol production have higher risks of developing finger osteoarthritis.
更年期和绝经后妇女手部骨关节炎的风险因素--等醇生成能力和家族史。横断面研究。
背景:手部疾病是更年期妇女的常见病。等醇是一种在人体内产生的大豆代谢物,其产生水平因人而异。本研究的目的是调查表明更年期和绝经后妇女体内戊醇产生水平的变量与手部疾病发生之间的相关关系:将女性受试者分为两组:患有手部骨关节炎的 45-70 岁女性(患者组)和没有手部骨关节炎的同龄女性(对照组)。我们通过测量尿液中的马勃醇浓度来估算每位受试者的马勃醇分泌水平。我们还调查了受试者的骨关节炎家族史:结果:患者组的等醇水平明显低于对照组(P<0.05):绝经早期出现手部症状(即手部僵硬和关节炎)的女性在绝经晚期和绝经后往往会发展为手部骨关节炎,这可能会导致她们的生活质量明显下降。虽然有人怀疑妇女患手部骨关节炎的概率与她们的临床背景(即家族史)有关,但尚未对此进行深入研究。我们对有和没有希伯登氏结节和布沙尔氏结节的女性进行的调查发现,女性患骨关节炎的概率与家族病史之间存在显著的相关性。我们还发现,妇女患手部骨关节炎的可能性与她们的马勃醇分泌水平之间存在明显的相关性。这些结果表明,有手指骨关节炎家族史和马勃醇分泌量低的女性患手指骨关节炎的风险较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Orthopaedic Science
Journal of Orthopaedic Science 医学-整形外科
CiteScore
3.00
自引率
0.00%
发文量
290
审稿时长
90 days
期刊介绍: The Journal of Orthopaedic Science is the official peer-reviewed journal of the Japanese Orthopaedic Association. The journal publishes the latest researches and topical debates in all fields of clinical and experimental orthopaedics, including musculoskeletal medicine, sports medicine, locomotive syndrome, trauma, paediatrics, oncology and biomaterials, as well as basic researches.
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