Psoriasis and steatotic liver disease: Are PNPLA3 and TM6SF2 polymorphisms suitable for the hepato-dermal axis hypothesis?

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Luciana Agoglia , Ana Carolina Cardoso , Lívia Barbosa , Cecília Schubert Xavier Lagalhard Victer , Sueli Carneiro , Paulo Henrique Condeixa de França , Maria Chiara Chindamo , Cristiane Alves Villela-Nogueira
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引用次数: 0

Abstract

Introduction and Objectives

A high prevalence of steatotic liver disease has been described in psoriasis. However, the influence of genetic polymorphisms has yet to be investigated in this scenario. This study aims to determine the frequency of steatosis, advanced liver fibrosis and PNPLA3/TM6SF2 genotypes in individuals with psoriasis and to evaluate the impact of genetic polymorphisms, metabolic parameters and cumulative methotrexate dose on steatosis and fibrosis.

Materials and Methods

Cross-sectional study that prospectively included psoriasis outpatients, submitted to clinical and laboratory analysis, transient elastography (FibroScan®, Fr) and PNPLA3/TM6SF2 genotyping. Steatosis was defined by CAP ≥275 dB/m and advanced liver fibrosis as transient elastography ≥10 kPa. Logistic regression analysis evaluated the independent variables related to steatosis and fibrosis; p-value< 0.05 was considered significant.

Results

One hundred and ninety-nine patients were enrolled (age 54.6 ± 12.6 years, 57.3% female). Metabolic syndrome (MetS), steatosis and advanced liver fibrosis prevalence were 55.8%, 54.8% and 9%, respectively. PNPLA3 and TM6SF2 genotypes frequencies were CC 42.3%/CG 49.5%/GG 8.2% and CC 88.7%/ CT 11.3%/ TT 0%. MetS (OR3.01 95%CI 1.51-5.98; p = 0.002) and body mass index (OR1.17 95%CI 1.08-1.26; p < 0.01) were independently associated with steatosis. Diabetes Mellitus (T2DM) (OR10.76 95%CI 2.42-47.87; p = 0.002) and harboring at least one PNPLA3 G allele (OR5.66 95%CI 1.08-29.52; p = 0.039) were associated with advanced fibrosis, but not TM6SF2 polymorphism or cumulative MTX dose.

Conclusions

MetS and T2DM confer higher odds for steatosis and advanced fibrosis in individuals with psoriasis. PNPLA3 G allele, but not TM6SF2 polymorphism, impacts a 5-fold odds of advanced liver fibrosis.

牛皮癣和脂肪肝:PNPLA3 和 TM6SF2 多态性是否适合肝-皮轴假说?
引言和目的:牛皮癣中脂肪肝的发病率很高。然而,在这种情况下,遗传多态性的影响还有待研究。本研究旨在确定银屑病患者脂肪变性、晚期肝纤维化和 PNPLA3/TM6SF2 基因型的频率,并评估基因多态性、代谢参数和甲氨蝶呤累积剂量对脂肪变性和肝纤维化的影响:横断面研究:前瞻性纳入银屑病门诊患者,对其进行临床和实验室分析、瞬态弹性成像(FibroScan®,Fr)和PNPLA3/TM6SF2基因分型。CAP≥275 dB/m定义为脂肪变性,瞬态弹性成像≥10 kPa定义为晚期肝纤维化。逻辑回归分析评估了与脂肪变性和肝纤维化相关的自变量;P值< 0.05为显著:共登记了 199 名患者(年龄为 54.6 ±12.6 岁,57.3% 为女性)。代谢综合征(MetS)、脂肪变性和晚期肝纤维化的发病率分别为 55.8%、54.8% 和 9%。PNPLA3和TM6SF2基因型频率分别为CC 42.3%/CG 49.5%/GG 8.2%和CC 88.7%/ CT 11.3%/ TT 0%。MetS(OR3.01 95%CI 1.51-5.98;p=0.002)和体重指数(OR1.17 95%CI 1.08-1.26;p结论:MetS和T2DM使银屑病患者发生脂肪变性和晚期纤维化的几率更高。PNPLA3 G等位基因(而非TM6SF2多态性)会使晚期肝纤维化的几率增加5倍。
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来源期刊
Annals of hepatology
Annals of hepatology 医学-胃肠肝病学
CiteScore
7.90
自引率
2.60%
发文量
183
审稿时长
4-8 weeks
期刊介绍: Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
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