Long-term clinical sequelae and socio-professional performance in craniopharyngioma patients.

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Minerva endocrinology Pub Date : 2024-09-01 Epub Date: 2024-02-15 DOI:10.23736/S2724-6507.22.03719-8
Inês Cosme, Ana R Gomes, Dinis Reis, Ema L Nobre, Maria I Alexandre, Vânia Gomes, Pedro Marques, Catarina Silvestre
{"title":"Long-term clinical sequelae and socio-professional performance in craniopharyngioma patients.","authors":"Inês Cosme, Ana R Gomes, Dinis Reis, Ema L Nobre, Maria I Alexandre, Vânia Gomes, Pedro Marques, Catarina Silvestre","doi":"10.23736/S2724-6507.22.03719-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Craniopharyngioma (CP) is a rare tumor, leading to several post-treatment sequelae which may have significant clinical and social implications, including impaired academic performance or employability.</p><p><strong>Methods: </strong>We conducted a retrospective study involving CP patients followed at our center between 1986 and 2020. Data on demographics, clinical, imaging, and treatment characteristics were collected from the clinical records.</p><p><strong>Results: </strong>There were 33 patients (current mean age of 49.8±18.7 years), being 22 diagnosed in adulthood. The average follow-up duration was 16.03±9.3 years. Twelve patients were treated with surgery alone, while 21 underwent surgery and radiotherapy. Pituitary and hypothalamic deficits were more frequent in treated with surgery, whereas visual defects and metabolic diseases were more frequent in treated with surgery and radiotherapy. There were no differences between age of onset groups and type of sequelae. After diagnosis, nine patients concluded their academic training. In childhood-onset group, after diagnosis, one patient was retired, three continue studying and the others concluded schooling. In the other group, six patients were retired and two concluded schooling. There was no association between academic performance or employability and the type of treatment. CP patients academic performance was not worse comparing with general Portuguese population.</p><p><strong>Conclusions: </strong>Long-term sequelae may not be related with the age of CP onset, but may vary according to the type of treatment. There was a wide variety of clinical sequelae with extended follow-up, however academic performance and employability seemed not affected. CP diagnosis in an early period of life may not compromise the academic success of patients.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"253-261"},"PeriodicalIF":2.5000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minerva endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/S2724-6507.22.03719-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Craniopharyngioma (CP) is a rare tumor, leading to several post-treatment sequelae which may have significant clinical and social implications, including impaired academic performance or employability.

Methods: We conducted a retrospective study involving CP patients followed at our center between 1986 and 2020. Data on demographics, clinical, imaging, and treatment characteristics were collected from the clinical records.

Results: There were 33 patients (current mean age of 49.8±18.7 years), being 22 diagnosed in adulthood. The average follow-up duration was 16.03±9.3 years. Twelve patients were treated with surgery alone, while 21 underwent surgery and radiotherapy. Pituitary and hypothalamic deficits were more frequent in treated with surgery, whereas visual defects and metabolic diseases were more frequent in treated with surgery and radiotherapy. There were no differences between age of onset groups and type of sequelae. After diagnosis, nine patients concluded their academic training. In childhood-onset group, after diagnosis, one patient was retired, three continue studying and the others concluded schooling. In the other group, six patients were retired and two concluded schooling. There was no association between academic performance or employability and the type of treatment. CP patients academic performance was not worse comparing with general Portuguese population.

Conclusions: Long-term sequelae may not be related with the age of CP onset, but may vary according to the type of treatment. There was a wide variety of clinical sequelae with extended follow-up, however academic performance and employability seemed not affected. CP diagnosis in an early period of life may not compromise the academic success of patients.

颅咽管瘤患者的长期临床后遗症和社会职业表现。
背景:颅咽管瘤(CP)是一种罕见的肿瘤:颅咽管瘤(CP)是一种罕见的肿瘤,治疗后会产生一些后遗症,可能会对临床和社会产生重大影响,包括影响学习成绩或就业能力:我们进行了一项回顾性研究,研究对象是1986年至2020年间在本中心接受随访的CP患者。我们从临床记录中收集了有关人口统计学、临床、影像学和治疗特征的数据:共有 33 名患者(当前平均年龄为 49.8±18.7 岁),其中 22 人在成年后确诊。平均随访时间为(16.03±9.3)年。12名患者仅接受了手术治疗,21名患者接受了手术和放射治疗。接受手术治疗的患者多伴有垂体和下丘脑功能障碍,而接受手术和放疗的患者多伴有视力缺陷和代谢性疾病。各组发病年龄和后遗症类型之间没有差异。确诊后,9 名患者结束了学术培训。儿童发病组中,1 名患者确诊后退休,3 名患者继续学习,其他患者结束学业。另一组中,6 名患者退休,2 名患者完成学业。学习成绩或就业能力与治疗类型之间没有关联。与葡萄牙普通人群相比,CP 患者的学习成绩并不差:长期后遗症可能与CP发病年龄无关,但可能因治疗方式而异。随着随访时间的延长,临床后遗症的种类繁多,但学习成绩和就业能力似乎并未受到影响。在早期诊断出脊髓灰质炎可能不会影响患者的学业成就。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.60
自引率
0.00%
发文量
146
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信