Phantom study and clinical application of total-body 18F-FDG PET/CT imaging: How to use small voxel imaging better?

IF 3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Chi Qi, Xiuli Sui, Haojun Yu, Siyang Wang, Yan Hu, Hongyan Sun, Xinlan Yang, Yihan Wang, Yun Zhou, Hongcheng Shi
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引用次数: 0

Abstract

Background: Conventional PET/CT imaging reconstruction is typically performed using voxel size of 3.0-4.0 mm in three axes. It is hypothesized that a smaller voxel sizes could improve the accuracy of small lesion detection. This study aims to explore the advantages and conditions of small voxel imaging on clinical application.

Methods: Both NEMA IQ phantom and 30 patients with an injected dose of 3.7 MBq/kg were scanned using a total-body PET/CT (uEXPLORER). Images were reconstructed using matrices of 192 × 192, 512 × 512, and 1024 × 1024 with scanning duration of 3 min, 5 min, 8 min, and 10 min, respectively.

Results: In the phantom study, the contrast recovery coefficient reached the maximum in matrix group of 512 × 512, and background variability increased as voxel size decreased. In the clinical study, SUVmax, SD, and TLR increased, while SNR decreased as the voxel size decreased. When the scanning duration increased, SNR increased, while SUVmax, SD, and TLR decreased. The SUVmean was more reluctant to the changes in imaging matrix and scanning duration. The mean subjective scores for all 512 × 512 groups and 1024 × 1024 groups (scanning duration ≥ 8 min) were over three points. One false-positive lesion was found in groups of 512 × 512 with scanning duration of 3 min, 1024 × 1024 with 3 min and 5 min, respectively. Meanwhile, the false-negative lesions found in group of 192 × 192 with duration of 3 min and 5 min, 512 × 512 with 3 min and 1024 × 1024 with 3 min and 5 min were 5, 4, 1, 4, and 1, respectively. The reconstruction time and storage space occupation were significantly increased as the imaging matrix increased.

Conclusions: PET/CT imaging with smaller voxel can improve SUVmax and TLR of lesions, which is advantageous for the diagnosis of small or hypometabolic lesions if with sufficient counts. With an 18F-FDG injection dose of 3.7 MBq/kg, uEXPLORER PET/CT imaging using matrix of 512 × 512 with 5 min or 1024 × 1024 with 8 min can meet the image requirements for clinical use.

全身 18F-FDG PET/CT 成像的模型研究与临床应用:如何更好地使用小体素成像?
背景:传统的 PET/CT 成像重建通常使用三轴 3.0-4.0 毫米的体素尺寸。据推测,更小的体素尺寸可以提高小病灶检测的准确性。本研究旨在探讨小体素成像在临床应用中的优势和条件:方法:使用全身正电子发射计算机断层显像仪(uEXPLORER)对NEMA IQ模型和30名注射剂量为3.7 MBq/kg的患者进行扫描。使用 192 × 192、512 × 512 和 1024 × 1024 的矩阵重建图像,扫描时间分别为 3 分钟、5 分钟、8 分钟和 10 分钟:在模型研究中,对比度恢复系数在 512 × 512 矩阵组中达到最大值,背景变异性随着体素大小的减小而增加。在临床研究中,随着体素尺寸的减小,SUVmax、SD 和 TLR 增加,而 SNR 下降。当扫描持续时间增加时,信噪比增加,而 SUVmax、SD 和 TLR 下降。SUVmean 对成像矩阵和扫描时间的变化更不敏感。所有 512 × 512 组和 1024 × 1024 组(扫描时间≥ 8 分钟)的平均主观评分均超过 3 分。扫描时间为 3 分钟的 512 × 512 组、扫描时间为 3 分钟的 1024 × 1024 组和扫描时间为 5 分钟的 1024 × 1024 组分别发现了一个假阳性病灶。同时,在扫描时间为 3 分钟和 5 分钟的 192 × 192 组、扫描时间为 3 分钟的 512 × 512 组以及扫描时间为 3 分钟和 5 分钟的 1024 × 1024 组发现的假阴性病灶分别为 5、4、1、4 和 1 个。随着成像矩阵的增加,重建时间和存储空间占用也明显增加:较小体素的 PET/CT 成像可提高病变的 SUVmax 和 TLR,在足够计数的情况下,有利于诊断小病变或低代谢病变。在 18F-FDG 注射剂量为 3.7 MBq/kg 的情况下,使用 5 分钟 512 × 512 或 8 分钟 1024 × 1024 的矩阵进行 uEXPLORER PET/CT 成像可以满足临床使用的图像要求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
EJNMMI Physics
EJNMMI Physics Physics and Astronomy-Radiation
CiteScore
6.70
自引率
10.00%
发文量
78
审稿时长
13 weeks
期刊介绍: EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
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