Prevalence of arterial stiffness and associated factors in Thai hemodialysis patients: A multicenter cross-sectional study.

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2024-05-01 DOI:10.5414/CN111187

Nuanjanthip Naiyarakseree, Jeerath Phannajit, Wichai Naiyarakseree, Thana Thongsricome, Nanta Mahatanan, Pagaporn Asavapujanamanee, Sookruetai Lekhyananda, Supat Vanichakarn, Yingyos Avihingsanon, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong

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引用次数: 0

Abstract

Background: Hemodialysis (HD) patients have higher risks of cardiovascular morbidity and mortality compared to the general population. Cardio-femoral pulse wave velocity (cfPWV) is associated with cardiovascular morbidity and mortality in HD patients. This study aimed to evaluate the prevalence and associated factors of arterial stiffness in Thai HD patients.

Materials and methods: This cross-sectional multicenter study was conducted at 4 HD centers in Bangkok, Thailand. cfPWV and peripheral blood pressure were assessed using SphygmoCor XCEL Model EM4C (AtCor medical Inc., Sydney, Australia). Significant arterial stiffness was defined by cfPWV > 10 m/s. Univariate and multivariable regression models were used to identify factors associated with arterial stiffness.

Results: 144 HD patients were assessed for arterial stiffness by cfPWV measurement. The mean age of the patients was 57.8 ± 12.8 years, with 50% male and a mean dialysis vintage of 7.6 years. The mean cfPWV was 11.7 ± 3.0 m/s. The prevalence of increased arterial stiffness was 73.6%. Multivariable analysis showed that older age, hypertension, lower HD adequacy, and higher fasting plasma glucose were independently associated with arterial stiffness.

Conclusion: There was a high prevalence of arterial stiffness among HD patients. Some modifiable factors found to be independently associated, including dialysis adequacy and glycemic control, should be further investigated to identify approaches to retard vascular stiffness.

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泰国血液透析患者动脉僵化的患病率及相关因素：一项多中心横断面研究。

背景：与普通人群相比，血液透析（HD）患者的心血管发病率和死亡率风险较高。心-股脉搏波速度（cfPWV）与血液透析患者的心血管发病率和死亡率有关。本研究旨在评估泰国 HD 患者动脉僵化的患病率和相关因素：这项横断面多中心研究在泰国曼谷的 4 家 HD 中心进行。使用 SphygmoCor XCEL Model EM4C（AtCor 医疗公司，澳大利亚悉尼）对 cfPWV 和外周血压进行评估。明显的动脉僵化定义为 cfPWV > 10 m/s。采用单变量和多变量回归模型确定与动脉僵化相关的因素：通过测量 cfPWV，对 144 名 HD 患者进行了动脉僵化评估。患者的平均年龄为 57.8 ± 12.8 岁，50% 为男性，平均透析年限为 7.6 年。平均 cfPWV 为 11.7 ± 3.0 m/s。动脉僵化增加的发生率为 73.6%。多变量分析表明，年龄较大、高血压、较低的血液透析充分性和较高的空腹血浆葡萄糖与动脉僵化有独立关联：结论：在血液透析患者中，动脉僵化的发病率很高。应进一步研究一些可改变的因素，包括透析充分性和血糖控制，以确定延缓血管僵化的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.