Retinopathy as a predictive indicator for significant hepatic fibrosis according to T2DM status: A cross-sectional study based on the national health and nutrition examination survey data

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jinze Li , Yi Xiang , Jiahao Han , Youfang Gao , Ruiying Wang , Zihe Dong , Huihui Chen , Ruixia Gao , Chuan Liu , Gao-Jun Teng , Xiaolong Qi
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引用次数: 0

Abstract

Introduction and Objectives

Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with a range of complications, with retinopathy being particularly common. Recent studies have shed light on a potential connection between diabetic retinopathy (DR) and hepatic fibrosis, indicating a possible shared pathophysiological foundation in T2DM. This study investigates the correlation between retinopathy and hepatic fibrosis among individuals with T2DM, as well as evaluates the diagnostic value of DR for significant hepatic fibrosis.

Materials and Methods

Our cross-sectional analysis incorporated 5413 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. The Fibrosis-4 score (FIB-4) classified hepatic fibrosis into different grades (F0-F4), with significant hepatic fibrosis marked as F2 or higher. Retinopathy severity was determined using retinal imaging and categorized into four levels. The analysis of variance or Chi-square tests facilitated group comparisons. Additionally, the receiver operating characteristic (ROC) analysis appraised the predictive accuracy of retinopathy for significant hepatic fibrosis in the T2DM population.

Results

Among 5413 participants, the mean age was 59.56 ± 12.41, with 50.2% male. And 20.6% were diagnosed with T2DM. Hepatic fibrosis grading was positively associated with retinopathy severity (OR [odds ratio]: 1.521, 95%CI [confidence interval]: 1.152-2.008, P = 0.003) across the entire population. The association was amplified in the T2DM population according to Pearson's analysis results. The ROC curve demonstrated retinopathy's diagnostic capacity for significant hepatic fibrosis in the T2DM population (AUC [area under curve] = 0.72, 95%CI: 0.651-0.793, P < 0.001).

Conclusions

Retinopathy could serve as an independent predictor of significant hepatic fibrosis in T2DM population. Ophthalmologists are advised to closely monitor T2DM patients with retinopathy.

视网膜病变是根据 T2DM 状态预测重大肝纤维化的指标:基于国家健康与营养调查数据的横断面研究。
导言和目标:2 型糖尿病(T2DM)是一种常见的代谢性疾病,通常与一系列并发症并存,其中视网膜病变尤为常见。最近的研究揭示了糖尿病视网膜病变(DR)与肝纤维化之间的潜在联系,表明 T2DM 可能具有共同的病理生理基础。本研究调查了 T2DM 患者视网膜病变与肝纤维化之间的相关性,并评估了 DR 对显著肝纤维化的诊断价值:我们的横断面分析纳入了 2005-2008 年美国国家健康与营养调查(NHANES)的 5413 名参与者。肝纤维化-4评分(FIB-4)将肝纤维化分为不同等级(F0-F4),F2或更高为严重肝纤维化。视网膜病变的严重程度通过视网膜成像确定,并分为四级。方差分析或卡方检验有助于进行分组比较。此外,接收器操作特征(ROC)分析评估了视网膜病变对 T2DM 患者肝纤维化的预测准确性:在 5413 名参与者中,平均年龄为(59.56±12.41)岁,男性占 50.2%。20.6%确诊为 T2DM。在整个人群中,肝纤维化分级与视网膜病变严重程度呈正相关(OR[几率比]:1.521,95%CI[置信区间]:1.152-2.008,P=0.003)。根据皮尔逊分析结果,这一关联在 T2DM 群体中被放大。ROC 曲线显示,视网膜病变在 T2DM 群体中具有诊断重大肝纤维化的能力(AUC [曲线下面积] = 0.72,95%CI:0.651-0.793,PC 结论:视网膜病变可作为 T2DM 患者肝纤维化的独立预测指标。建议眼科医生密切监测患有视网膜病变的 T2DM 患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of hepatology
Annals of hepatology 医学-胃肠肝病学
CiteScore
7.90
自引率
2.60%
发文量
183
审稿时长
4-8 weeks
期刊介绍: Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
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