The Age-Male-Albumin-Bilirubin-Platelets (aMAP) Risk Score Predicts Liver Metastasis Following Surgery for Breast Cancer in Chinese Population: A Retrospective Study.

IF 6.2 Q1 IMMUNOLOGY
ImmunoTargets and Therapy Pub Date : 2024-02-08 eCollection Date: 2024-01-01 DOI:10.2147/ITT.S446545
Li Chen, Qiang Liu, Chunlei Tan, Tiangen Wu, Meng Wu, Xiaosheng Tan, Jinwen Liu, Jing Wang
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引用次数: 0

Abstract

Objective: The current study is conducted to investigate the potential prognostic value of the age-male-albumin-bilirubin-platelets (aMAP) score in breast cancer patients with liver metastasis after surgery.

Methods: This is a retrospective study of 178 breast cancer patients who developed liver metastasis after surgery. These patients were treated and followed up from 2000 to 2018 at our hospital. The aMAP risk score was estimated in accordance with the following formula: . The optimal cutoff value of the aMAP was evaluated via X-tile. Kaplan-Meier, Log-rank and Cox proportional hazards regression models were applied to determine the clinical influence of the aMAP score on the survival outcomes. The nomogram models were established by multivariate analyses. The calibration curves and decision curve analysis were applied to evaluate the estimated performance of the nomogram models.

Results: A total of 178 breast cancer patients were divided into low aMAP score group (<47.6) and high aMAP score group (≥47.6) via X-tile plots. The aMAP score was a potential prognostic factor in multivariate analysis. The median disease free survival (p=0.0013) and overall survival (p=0.0003) in low aMAP score group were longer than in high aMAP score group. The nomograms were constructed to predict the DFS with a C-index of 0.722 (95% CI, 0.673-0.771), and the OS with a C-index of 0.708 (95% CI, 0.661-0.755). The aMAP-based nomograms had good predictive performance.

Conclusion: The aMAP score is a potential prognostic factor in breast cancer with liver metastasis after surgery. The aMAP score-based nomograms were conducive to discriminate patients at high risks of liver metastasis and develop adjuvant treatment and prevention strategies.

年龄-男性-白蛋白-胆红素-血小板(aMAP)风险评分预测中国人群乳腺癌术后肝转移:一项回顾性研究
目的本研究旨在探讨年龄-男性-白蛋白-胆红素-血小板(aMAP)评分在乳腺癌术后肝转移患者中的潜在预后价值:这是一项回顾性研究,研究对象是178名术后出现肝转移的乳腺癌患者。这些患者于 2000 年至 2018 年在我院接受治疗和随访。aMAP 风险评分按照以下公式估算:.通过 X-tile 评估 aMAP 的最佳临界值。采用 Kaplan-Meier、Log-rank 和 Cox 比例危险回归模型来确定 aMAP 评分对生存结果的临床影响。通过多变量分析建立了提名图模型。校准曲线和决策曲线分析用于评估提名图模型的估计性能:结果:共有 178 名乳腺癌患者被分为 aMAP 评分低的一组(结论:aMAP 评分是乳腺癌患者生存预后的潜在指标:aMAP 评分是乳腺癌术后肝转移的潜在预后因素。基于 aMAP 评分的提名图有利于区分肝转移高风险患者,并制定辅助治疗和预防策略。
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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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