Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Biology of Sex Differences Pub Date : 2024-02-13 DOI:10.1186/s13293-024-00591-6

Shefali Chaudhary, Hak Kei Wong, Yu Chen, Sheng Zhang, Chiang-Shan R Li

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引用次数: 0

Abstract

Background: Men and women are known to show differences in the incidence and clinical manifestations of mood and anxiety disorders. Many imaging studies have investigated the neural correlates of sex differences in emotion processing. However, it remains unclear how anxiety might impact emotion processing differently in men and women.

Method: We recruited 119 healthy adults and assessed their levels of anxiety using State-Trait Anxiety Inventory (STAI) State score. With functional magnetic resonance imaging (fMRI), we examined regional responses to negative vs. neutral (Neg-Neu) picture matching in the Hariri task. Behavioral data were analyzed using regression and repeated-measures analysis of covariance with age as a covariate, and fMRI data were analyzed using a full-factorial model with sex as a factor and age as a covariate.

Results: Men and women did not differ in STAI score, or accuracy rate or reaction time (RT) (Neg-Neu). However, STAI scores correlated positively with RT (Neg-Neu) in women but not in men. Additionally, in women, STAI score correlated positively with lingual gyrus (LG) and negatively with medial prefrontal cortex (mPFC) and superior frontal gyrus (SFG) activity during Neg vs. Neu trials. The parameter estimates (βs) of mPFC also correlated with RT (Neg-Neu) in women but not in men. Generalized psychophysiological interaction (gPPI) analysis in women revealed mPFC connectivity with the right inferior frontal gyrus, right SFG, and left parahippocampal gyrus during Neg vs. Neu trials in positive correlation with both STAI score and RT (Neg-Neu). In a mediation analysis, mPFC gPPI but not mPFC activity fully mediated the association between STAI scores and RT (Neg-Neu).

Conclusion: With anxiety affecting the behavioral and neural responses to negative emotions in women but not in men and considering the known roles of the mPFC in emotion regulation, we discussed heightened sensitivity and regulatory demands during negative emotion processing as neurobehavioral markers of anxiety in women.

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个体焦虑状态对负面情绪场景区域反应的影响存在性别差异。

背景：众所周知，男性和女性在情绪和焦虑症的发病率和临床表现方面存在差异。许多影像学研究都对情绪处理中的性别差异的神经相关性进行了调查。然而，目前仍不清楚焦虑会如何对男性和女性的情绪处理产生不同的影响：方法：我们招募了 119 名健康成年人，并使用状态-特质焦虑量表（STAI）状态评分评估了他们的焦虑水平。通过功能磁共振成像（fMRI），我们研究了哈里里任务中负性与中性（Neg-Neu）图片匹配的区域反应。行为数据采用回归和重复测量协方差分析法进行分析，年龄为协方差；fMRI 数据采用全因子模型进行分析，性别为因子，年龄为协方差：男性和女性在STAI得分、准确率或反应时间（RT）（Neg-Neu）方面没有差异。但是，女性的 STAI 分数与 RT（Neg-Neu）呈正相关，而男性则不然。此外，在Neg与Neu试验中，女性的STAI得分与舌回（LG）呈正相关，而与内侧前额叶皮层（mPFC）和额上回（SFG）的活动呈负相关。在女性中，mPFC 的参数估计（βs）也与 RT（Neg-Neu）相关，但在男性中则不相关。对女性进行的广义心理生理学交互作用（gPPI）分析显示，在 "否定 "与 "新 "的试验中，mPFC与右侧额叶下回、右侧SFG和左侧海马旁回的连接与STAI得分和RT（"否定 "与 "新"）呈正相关。在中介分析中，mPFC gPPI而非mPFC活动完全中介了STAI得分和RT（Neg-Neu）之间的关联：结论：焦虑会影响女性而非男性对负面情绪的行为和神经反应，考虑到 mPFC 在情绪调节中的已知作用，我们讨论了女性在负面情绪处理过程中作为焦虑神经行为标记的高度敏感性和调节需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biology of Sex Differences ENDOCRINOLOGY & METABOLISM-GENETICS & HEREDITY

CiteScore

12.10

自引率

1.30%

发文量

审稿时长

14 weeks

期刊介绍： Biology of Sex Differences is a unique scientific journal focusing on sex differences in physiology, behavior, and disease from molecular to phenotypic levels, incorporating both basic and clinical research. The journal aims to enhance understanding of basic principles and facilitate the development of therapeutic and diagnostic tools specific to sex differences. As an open-access journal, it is the official publication of the Organization for the Study of Sex Differences and co-published by the Society for Women's Health Research. Topical areas include, but are not limited to sex differences in: genomics; the microbiome; epigenetics; molecular and cell biology; tissue biology; physiology; interaction of tissue systems, in any system including adipose, behavioral, cardiovascular, immune, muscular, neural, renal, and skeletal; clinical studies bearing on sex differences in disease or response to therapy.