Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Fadi Alkhami, Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Marie-Amélie Barbet-Massin, Amandine Ferriere, Claire Ducos, Kamel Mohammedi, Sami Fawaz, Thierry Couffinhal, Vincent Rigalleau
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Abstract

Background

Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM.

Research design and methods

We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death). The relationship between SAF and CVE was analyzed by multivariable Cox regression. Log-rank curves were used to compare CVE-free survival in patients whose SAF at admission was above versus below the whole-population median. The analysis was repeated in subjects without/with macroangiopathy (defined as myocardial infarction, stroke, peripheral revascularization) at baseline.

Findings

During 54 months of follow-up, 69 (13.7%) patients had a CVE. Baseline SAF was significantly higher in patients with T2DM who later experienced a CVE (2.89 ± 0.70 arbitrary units versus 2.64 ± 0.62 in others, P = 0.002). This relationship was significant after adjusting for age, sex, conventional risk factors (diabetes duration, HbA1c, arterial hypertension, dyslipidemia, smoking, body mass index), vascular complications, C-reactive protein, and treatments for diabetes. The CVE-free survival curves differed between subjects whose SAF was above the whole-population median (log-rank: P = 0.002) and those whose SAF was above the macroangiopathy-free sub-population median (log-rank: P = 0.016).

Conclusion

SAF of advanced glycation end-products was related to a higher incidence of later CVE in patients with T2DM.

皮肤高级糖化终产物自发荧光与 2 型糖尿病新发心血管事件的关系:一项纵向观察研究。
背景:心血管疾病是2型糖尿病(T2DM)的常见病。我们研究了T2DM患者皮肤高级糖化终产物自发荧光(SAF)与日后心血管事件(CVEs)之间的关系:我们对 2009 年至 2017 年间 504 名因未控制和/或复杂 T2DM 而住院的患者进行了回顾性分析。使用 AGE-Reader 测量了 SAF。从入院到 2020 年 12 月,我们对参与者的 CVE(心肌梗死、中风、血管重建手术或心血管死亡)发病情况进行了随访。通过多变量考克斯回归分析了SAF与CVE之间的关系。使用对数秩曲线比较入院时SAF高于和低于全人群中位数的患者无CVE生存率。对基线时无/有大血管病变(定义为心肌梗死、中风、外周血管再通术)的受试者进行了重复分析:在54个月的随访期间,69名(13.7%)患者出现了CVE。后来发生 CVE 的 T2DM 患者的基线 SAF 明显更高(2.89 ± 0.70 任意单位,其他患者为 2.64 ± 0.62,P = 0.002)。在调整了年龄、性别、常规风险因素(糖尿病病程、HbA1c、动脉高血压、血脂异常、吸烟、体重指数)、血管并发症、C-反应蛋白和糖尿病治疗方法后,这一关系仍有意义。SAF高于全人群中位数(对数秩:P = 0.002)的受试者与SAF高于无大血管病变亚人群中位数(对数秩:P = 0.016)的受试者之间的无CVE生存曲线存在差异:结论:晚期糖化终末产物的SAF与T2DM患者日后CVE的较高发病率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetes & metabolism
Diabetes & metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.20%
发文量
86
审稿时长
13 days
期刊介绍: A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.
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