{"title":"Scrutinizing microbiome determinism: why deterministic hypotheses about the microbiome are conceptually ungrounded.","authors":"Javier Suárez","doi":"10.1007/s40656-024-00610-0","DOIUrl":null,"url":null,"abstract":"<p><p>This paper addresses the topic of determinism in contemporary microbiome research. I distinguish two types of deterministic claims about the microbiome, and I show evidence that both types of claims are present in the contemporary literature. First, the idea that the host genetics determines the composition of the microbiome which I call \"host-microbiome determinism\". Second, the idea that the genetics of the holobiont (the individual unit composed by a host plus its microbiome) determines the expression of certain phenotypic traits, which I call \"microbiome-phenotype determinism\". Drawing on the stability of traits conception of individuality (Suárez in Hist Philos Life Sci 42:11, 2020) I argue that none of these deterministic hypotheses is grounded on our current knowledge of how the holobiont is transgenerationally assembled, nor how it expresses its phenotypic traits.</p>","PeriodicalId":56308,"journal":{"name":"History and Philosophy of the Life Sciences","volume":"46 1","pages":"12"},"PeriodicalIF":1.6000,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10861753/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"History and Philosophy of the Life Sciences","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.1007/s40656-024-00610-0","RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HISTORY & PHILOSOPHY OF SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
This paper addresses the topic of determinism in contemporary microbiome research. I distinguish two types of deterministic claims about the microbiome, and I show evidence that both types of claims are present in the contemporary literature. First, the idea that the host genetics determines the composition of the microbiome which I call "host-microbiome determinism". Second, the idea that the genetics of the holobiont (the individual unit composed by a host plus its microbiome) determines the expression of certain phenotypic traits, which I call "microbiome-phenotype determinism". Drawing on the stability of traits conception of individuality (Suárez in Hist Philos Life Sci 42:11, 2020) I argue that none of these deterministic hypotheses is grounded on our current knowledge of how the holobiont is transgenerationally assembled, nor how it expresses its phenotypic traits.
本文探讨了当代微生物组研究中的决定论话题。我区分了两类关于微生物组的决定论主张，并展示了当代文献中存在这两类主张的证据。首先，宿主基因决定微生物组组成的观点，我称之为 "宿主-微生物组决定论"。其次，全生物体（由宿主及其微生物组组成的个体单元）的遗传学决定了某些表型特征的表达，我称之为 "微生物组-表型决定论"。借鉴个体性的性状稳定性概念（Suárez in Hist Philos Life Sci 42:11, 2020），我认为这些决定论假说都不符合我们目前对整体生物体如何跨代组合以及如何表达其表型性状的了解。
期刊介绍：
History and Philosophy of the Life Sciences is an interdisciplinary journal committed to providing an integrative approach to understanding the life sciences. It welcomes submissions from historians, philosophers, biologists, physicians, ethicists and scholars in the social studies of science. Contributors are expected to offer broad and interdisciplinary perspectives on the development of biology, biomedicine and related fields, especially as these perspectives illuminate the foundations, development, and/or implications of scientific practices and related developments. Submissions which are collaborative and feature different disciplinary approaches are especially encouraged, as are submissions written by senior and junior scholars (including graduate students).
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