Prevalence and Predictors of Diabetic Peripheral Neuropathy in Newly Diagnosed Type 2 Diabetes Mellitus Patients.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Pooja Jadhao, Jayshree Swain, Srijit Das, Swayamsidha Mangaraj, Surapaneni Lakshmi Sravya
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Abstract

Aim: The present study aimed to determine the prevalence and predictors of DPN in newly diagnosed T2DM patients.

Background: Diabetic Peripheral Neuropathy (DPN) is the most common and debilitating complication of Type 2 Diabetes Mellitus (T2DM).

Methods: Newly diagnosed T2DM patients visiting the outpatient department were recruited. Detailed demographic parameters, histories, physical examinations, and biochemical investigations were carried out. Patients were screened for DPN using the Diabetic Neuropathy Symptom (DNS) score, the revised Disability Neuropathy Score (NDS), Vibration Perception Threshold (VPT) using a biosthesiometer, and the 10g SW Monofilament Test (MFT).

Results: A total of 350 newly diagnosed T2DM patients (mean age 46.4±13.6 years) were included. The prevalence of DPN was found to be 34% using the combined DNS and NDS scores. VPT was moderately impaired in 18.3% and severely impaired in 12% patients, while MFT revealed a loss of protective sensation in 35.4% patients. After logistic regression analysis, DPN was significantly associated with increasing age (OR 1.08, 95%CI 1.06-1.11), increasing HbA1C levels (OR 1.23, 95%CI 1.05-1.42), increasing TSH levels (OR 1.23, 95%CI 1.05-1.44), presence of hypertension (OR 2.78, 95%CI 1.51-5.11), and reduced BMI (OR 0.9, 95%CI 0.84- 0.99). The sensitivity and specificity of detecting DPN by combining VPT and MFT were 91.6% and 84.2%, respectively.

Conclusion: The prevalence of DPN was high even in newly diagnosed T2DM and associated significantly with increasing age, HbA1C levels, TSH levels, hypertension, and reduced BMI. Earlier screening for DPN, along with aggressive control of glycemia, blood pressure, and hypothyroidism, may be beneficial.

新诊断的 2 型糖尿病患者中糖尿病周围神经病变的患病率和预测因素。
目的:本研究旨在确定新诊断的 T2DM 患者中 DPN 的患病率和预测因素:背景:糖尿病周围神经病变(DPN)是 2 型糖尿病(T2DM)最常见、最令人衰弱的并发症:方法:招募到门诊部就诊的新诊断 T2DM 患者。进行了详细的人口统计学参数、病史、体格检查和生化检查。使用糖尿病神经病变症状(DNS)评分、修订版残疾神经病变评分(NDS)、生物震颤仪振动感知阈值(VPT)和 10g SW 单丝测试(MFT)对患者进行 DPN 筛查:共纳入 350 名新确诊的 T2DM 患者(平均年龄为 46.4±13.6 岁)。根据 DNS 和 NDS 的综合评分,发现 DPN 的患病率为 34%。18.3% 的患者 VPT 中度受损,12% 的患者严重受损,而 35.4% 的患者 MFT 显示保护性感觉缺失。经过逻辑回归分析,DPN 与年龄增加(OR 1.08,95%CI 1.06-1.11)、HbA1C 水平增加(OR 1.23,95%CI 1.05-1.42)、促甲状腺激素水平增加(OR 1.23,95%CI 1.05-1.44)、高血压(OR 2.78,95%CI 1.51-5.11)和体重指数降低(OR 0.9,95%CI 0.84-0.99)显著相关。结合 VPT 和 MFT 检测 DPN 的敏感性和特异性分别为 91.6% 和 84.2%:结论:即使在新诊断的 T2DM 患者中,DPN 的患病率也很高,并且与年龄、HbA1C 水平、TSH 水平、高血压和体重指数(BMI)的增加显著相关。尽早筛查 DPN,同时积极控制血糖、血压和甲状腺功能减退症,可能会有所裨益。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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