Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-01-01 Epub Date: 2024-02-11 DOI:10.1080/15384101.2024.2311501

Jiyang Wu, Xiaoxing Wang, Zhengzhe Li, Xiaomei Yi, Die Hu, Qi Wang, Tianyu Zhong

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引用次数: 0

Abstract

Colorectal cancer (CRC) ranks among the most prevalent global malignancies, posing significant threats to human life and health due to its high recurrence and metastatic potential. Small extracellular vesicles (sEVs) released by CRC play a pivotal role in the formation of the pre-metastatic niche (PMN) through various mechanisms, preparing the groundwork for accelerated metastatic invasion. This review systematically describes how sEVs promote CRC metastasis by upregulating inflammatory factors, promoting immunosuppression, enhancing angiogenesis and vascular permeability, promoting lymphangiogenesis and lymphatic network remodeling, determining organophilicity, promoting stromal cell activation and remodeling and inducing the epithelial-to-mesenchymal transition (EMT). Furthermore, we explore potential mechanisms by which sEVs contribute to PMN formation in CRC and propose novel insights for CRC diagnosis, treatment, and prognosis.

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细胞外小泡通过多种机制促进结直肠癌转移前生态位的形成。

结肠直肠癌（CRC）是全球发病率最高的恶性肿瘤之一，因其复发率高和转移潜力大而对人类的生命和健康构成重大威胁。CRC 释放的细胞外小泡（sEVs）通过各种机制在转移前生态位（PMN）的形成过程中发挥着关键作用，为加速转移性侵袭奠定了基础。本综述系统阐述了 sEVs 如何通过上调炎症因子、促进免疫抑制、增强血管生成和血管通透性、促进淋巴管生成和淋巴网络重塑、决定嗜有机物性、促进基质细胞活化和重塑以及诱导上皮细胞向间质转化（EMT）来促进 CRC 转移。此外，我们还探讨了 sEVs 促进 CRC 中 PMN 形成的潜在机制，并为 CRC 的诊断、治疗和预后提出了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567