A meta-analysis of urinary transferrin for early diagnosis of diabetic nephropathy.

Laboratory medicine Pub Date : 2024-07-03 DOI:10.1093/labmed/lmad115

Bangjian Li, Jieying Wang, Wen Ye

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Abstract

Objective: To assess the diagnostic value of urinary transferrin (Tf) in early diabetic nephropathy (DN) to propose a more sensitive and noninvasive biomarker for screening and monitoring DN in clinical practice.

Methods: We searched 3 databases from their inception to May 2023, to identify studies investigating the diagnostic value of Tf in patients with DN. Meta-DiSc software, version 1.4, and Stata software, version 15.1 (StataCorp) were used to conduct a meta-analysis and evaluate the diagnostic accuracy of urine Tf levels for DN.

Results: The meta-analysis included 6 relevant studies investigating the diagnostic value of Tf level for DN. Urinary Tf as a diagnostic marker demonstrated a combined sensitivity of 0.82 (95% CI, 0.71-0.89) and specificity of 0.88 (0.84-0.92). the positive diagnostic likelihood ratio was 7.07 (4.57-10.93), the negative diagnostic likelihood ratio was 0.20 (0.12-0.35), and the diagnostic odds ratio was 34.49 (13.61-87.44). Also, the area under the receiver operating characteristic curve was 0.92 (0.89-0.94), indicating that urinary Tf has a decent discriminative ability in diagnosing DN.

Conclusion: Tf level is a valuable biological marker for early diagnosis and monitoring of DN in clinical practice. It has statistically significant predictive value for patients in the early phases of DN.

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尿转铁蛋白用于糖尿病肾病早期诊断的荟萃分析。

目的：评估尿转铁蛋白（Tf）在早期糖尿病肾病（DN）中的诊断价值：评估尿转铁蛋白（Tf）在早期糖尿病肾病（DN）中的诊断价值，为临床实践中筛查和监测DN提出一种更灵敏、无创的生物标志物：我们检索了从开始到 2023 年 5 月的 3 个数据库，以确定调查 Tf 对 DN 患者诊断价值的研究。使用 Meta-DiSc 软件 1.4 版和 Stata 软件 15.1 版（StataCorp）进行荟萃分析，评估尿 Tf 水平对 DN 的诊断准确性：荟萃分析纳入了 6 项调查 Tf 水平对 DN 诊断价值的相关研究。尿 Tf 作为诊断标志物的综合灵敏度为 0.82（95% CI，0.71-0.89），特异度为 0.88（0.84-0.92），阳性诊断似然比为 7.07（4.57-10.93），阴性诊断似然比为 0.20（0.12-0.35），诊断几率比为 34.49（13.61-87.44）。此外，接收者操作特征曲线下面积为 0.92（0.89-0.94），表明尿 Tf 在诊断 DN 方面具有良好的鉴别能力：结论：Tf水平是临床上早期诊断和监测DN的重要生物标志物。结论：在临床实践中，Tf水平是早期诊断和监测DN的重要生物标志物，对DN早期患者具有统计学意义上的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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