Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2024-02-06 DOI:10.1016/j.bbagrm.2024.195018

Tasniem Fetian, Aakash Grover, Karen M. Arndt

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引用次数: 0

Abstract

Nucleosomes are major determinants of eukaryotic genome organization and regulation. Many studies, incorporating a diversity of experimental approaches, have been focused on identifying and discerning the contributions of histone post-translational modifications to DNA-centered processes. Among these, monoubiquitylation of H2B (H2Bub) on K120 in humans or K123 in budding yeast is a critical histone modification that has been implicated in a wide array of DNA transactions. H2B is co-transcriptionally ubiquitylated and deubiquitylated via the concerted action of an extensive network of proteins. In addition to altering the chemical and physical properties of the nucleosome, H2Bub is important for the proper control of gene expression and for the deposition of other histone modifications. In this review, we discuss the molecular mechanisms underlying the ubiquitylation cycle of H2B and how it connects to the regulation of transcription and chromatin structure.

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组蛋白 H2B 泛素化：与转录的联系以及对染色质结构的影响

核小体是真核生物基因组组织和调控的主要决定因素。许多研究采用了不同的实验方法，重点研究组蛋白翻译后修饰对以 DNA 为中心的过程的贡献。其中，人类 H2B（H2Bub）在 K120 或芽殖酵母在 K123 上的单泛素化是一种关键的组蛋白修饰，与一系列 DNA 事务有关。通过广泛的蛋白质网络的协同作用，H2B 被共转录泛素化和去泛素化。除了改变核小体的化学和物理特性外，H2Bub 对于正确控制基因表达和沉积其他组蛋白修饰也很重要。在这篇综述中，我们将讨论 H2B 泛素化循环的分子机制及其与转录和染色质结构调控之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.