The role of NLRP3 inflammasome in type 2 inflammation related diseases.

IF 3.3 4区医学 Q3 IMMUNOLOGY

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-02-08 DOI:10.1080/08916934.2024.2310269

Shenming Xu, Dan Wang, Lina Tan, Jianyun Lu

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引用次数: 0

Abstract

Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse and affect multiple systems in the human body. It is common for individuals to have multiple co-existing type 2 inflammation related diseases, which can impose a significant financial and living burden on patients. However, the exact pathogenesis of these diseases is still unclear. The NLRP3 inflammasome is a protein complex composed of the NLRP3 protein, ASC, and Caspase-1, and is activated through various mechanisms, including the NF-κB pathway, ion channels, and lysosomal damage. The NLRP3 inflammasome plays a role in the immune response to pathogens and cellular damage. Recent studies have indicated a strong correlation between the abnormal activation of NLRP3 inflammasome and the onset of type 2 inflammation. Additionally, it has been demonstrated that suppressing NLRP3 expression effectively diminishes the inflammatory response, highlighting its promising therapeutic applications. Therefore, this article reviews the role of NLRP3 inflammasome in the development and therapy of multiple type 2 inflammation related diseases.

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NLRP3 炎症小体在 2 型炎症相关疾病中的作用。

2 型炎症相关疾病（如特应性皮炎、哮喘和过敏性鼻炎）种类繁多，影响人体多个系统。个人同时患有多种 2 型炎症相关疾病的情况很常见，这会给患者带来沉重的经济和生活负担。然而，这些疾病的确切发病机制仍不清楚。NLRP3 炎症小体是由 NLRP3 蛋白、ASC 和 Caspase-1 组成的蛋白复合物，通过 NF-κB 通路、离子通道和溶酶体损伤等多种机制被激活。NLRP3 炎性体在对病原体和细胞损伤的免疫反应中发挥作用。最近的研究表明，NLRP3 炎症小体的异常激活与 2 型炎症的发生密切相关。此外，研究还表明，抑制 NLRP3 的表达可有效减轻炎症反应，这突显了它的治疗应用前景。因此，本文综述了 NLRP3 炎症小体在多种 2 型炎症相关疾病的发展和治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity 医学-免疫学

CiteScore

5.70

自引率

8.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.