Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury.

IF 2.2 3区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Integrative Medicine Pub Date : 2024-10-01 Epub Date: 2024-02-08 DOI:10.1007/s11655-024-3657-0

Chang-Xing Liu, Xin-Yi Guo, Ya-Bin Zhou, He Wang

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引用次数: 0

Abstract

Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion therapy, though the preferred treatment for AMI, often exacerbates cardiac damage, leading to myocardial ischemia/reperfusion injury (MI/RI). Consequently, the development of strategies to reduce MI/RI is an urgent priority in cardiovascular therapy. Chinese medicine, recognized for its multi-component, multi-pathway, and multi-target capabilities, provides a novel approach for alleviating MI/RI. A key area of interest is the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. This pathway is instrumental in regulating inflammatory responses, oxidative stress, apoptosis, endoplasmic reticulum stress, and ferroptosis in MI/RI. This paper presents a comprehensive overview of the Nrf2/HO-1 signaling pathway's structure and its influence on MI/RI. Additionally, it reviews the latest research on leveraging Chinese medicine to modulate the Nrf2/HO-1 pathway in MI/RI treatment.

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靶向Nrf2/HO-1信号通路的中药在心肌缺血再灌注损伤中的治疗作用

急性心肌梗死（AMI）的发病率和死亡率都很高，对公众健康构成了重大威胁。再灌注疗法虽然是治疗急性心肌梗死的首选疗法，但往往会加重心脏损伤，导致心肌缺血/再灌注损伤（MI/RI）。因此，开发减少心肌缺血/再灌注损伤的策略是心血管治疗的当务之急。中药具有多成分、多途径、多靶点的特点，为减轻心肌缺血/再灌注损伤提供了一种新方法。核因子 E2 相关因子 2（Nrf2）/血红素加氧酶-1（HO-1）通路是一个关键领域。该通路有助于调节 MI/RI 中的炎症反应、氧化应激、细胞凋亡、内质网应激和铁蛋白沉积。本文全面概述了 Nrf2/HO-1 信号通路的结构及其对 MI/RI 的影响。此外，它还回顾了利用中药调节 Nrf2/HO-1 通路治疗 MI/RI 的最新研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Journal of Integrative Medicine 医学-全科医学与补充医学

CiteScore

5.90

自引率

3.40%

发文量

2413

审稿时长

3 months

期刊介绍： Chinese Journal of Integrative Medicine seeks to promote international communication and exchange on integrative medicine as well as complementary and alternative medicine (CAM) and provide a rapid forum for the dissemination of scientific articles focusing on the latest developments and trends as well as experiences and achievements on integrative medicine or CAM in clinical practice, scientific research, education and healthcare.