Low-frequency ultrasound for pulmonary hypertension therapy

IF 4.7 2区医学 Q1 RESPIRATORY SYSTEM

Respiratory Research Pub Date : 2024-02-05 DOI:10.1186/s12931-024-02713-5

Vytautas Ostasevicius, Vytautas Jurenas, Mantas Venslauskas, Laura Kizauskiene, Vilma Zigmantaite, Edgaras Stankevicius, Algimantas Bubulis, Joris Vezys, Sandra Mikuckyte

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引用次数: 0

Abstract

Currently, there are no reliable clinical tools that allow non-invasive therapeutic support for patients with pulmonary arterial hypertension. This study aims to propose a low-frequency ultrasound device for pulmonary hypertension therapy and to demonstrate its potential. A novel low-frequency ultrasound transducer has been developed. Due to its structural properties, it is excited by higher vibrational modes, which generate a signal capable of deeply penetrating biological tissues. A methodology for the artificial induction of pulmonary hypertension in sheep and for the assessment of lung physiological parameters such as blood oxygen concentration, pulse rate, and pulmonary blood pressure has been proposed. The results showed that exposure of the lungs to low-frequency ultrasound changed physiological parameters such as blood oxygen concentration, pulse rate and blood pressure. These parameters are most closely related to indicators of pulmonary hypertension (PH). The ultrasound exposure increased blood oxygen concentration over a 7-min period, while pulse rate and pulmonary blood pressure decreased over the same period. In anaesthetised sheep exposed to low-frequency ultrasound, a 10% increase in SpO2, a 10% decrease in pulse rate and an approximate 13% decrease in blood pressure were observed within 7 min. The research findings demonstrate the therapeutic efficiency of low-frequency ultrasound on hypertensive lungs, while also revealing insights into the physiological aspects of gas exchange within the pulmonary system.

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低频超声治疗肺动脉高压

目前，还没有可靠的临床工具可以为肺动脉高压患者提供无创治疗支持。本研究旨在提出一种用于肺动脉高压治疗的低频超声设备，并证明其潜力。我们开发了一种新型低频超声换能器。由于其结构特性，它能被较高的振动模式激发，从而产生能够深入穿透生物组织的信号。提出了一种人工诱导绵羊肺动脉高压和评估肺部生理参数（如血氧浓度、脉搏率和肺血压）的方法。结果表明，将肺暴露于低频超声波会改变血氧浓度、脉搏率和血压等生理参数。这些参数与肺动脉高压（PH）的指标关系最为密切。在 7 分钟的时间内，超声波照射增加了血氧浓度，而同期脉搏率和肺血压则下降了。麻醉绵羊暴露于低频超声波后，在7分钟内观察到SpO2增加10%，脉率降低10%，血压降低约13%。研究结果证明了低频超声对高血压肺部的治疗效果，同时也揭示了肺部系统内气体交换的生理方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Research 医学-呼吸系统

自引率

1.70%

发文量

314

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.