[Biological effects of coordinated compounds of transitional metals. 7. Antiviral activity of 4-methyl-2-aminopyridine palladium chloride against herpes simplex virus type 1 and type 2 in vitro and in vivo].

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology Pub Date : 1987-10-01

P Wutzler, K D Thiel, M Tonew, E Tonew, H P Schröer, A Stelzner

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Abstract

4-Methyl-2-amino-pyridine-palladium chloride (MAP) showed an antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a serum-free medium under in vitro conditions. The replication of these viruses on primary rabbit testes cells was completely suppressed by 10(-5) M/l MAP. In animal tests using ABD2-mice the course of HSV-1 and HSV-2 encephalitis was not influenced by MAP indicated by mean survival time and lethality.

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过渡金属配位化合物的生物效应。7. 4-甲基-2-氨基吡啶氯化钯对1型和2型单纯疱疹病毒的体外和体内抗病毒活性[j]。

4-甲基-2-氨基吡啶-氯化钯(MAP)在体外无血清培养基中对1型单纯疱疹病毒(HSV-1)和2型单纯疱疹病毒(HSV-2)具有抗病毒活性。10(-5) M/l MAP可完全抑制这些病毒在兔原代睾丸细胞上的复制。在abd2 -小鼠的动物实验中，MAP对HSV-1和HSV-2脑炎病程的影响不受平均生存时间和致死率的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology

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