Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR)

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Helena Trevisan Schroeder , Carlos Henrique De Lemos Muller , Thiago Gomes Heck , Mauricio Krause , Paulo Ivo Homem de Bittencourt Jr
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Abstract

Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition characterizes a spectrum of debilitating conditions, including insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments. This manuscript explores a range of physiological, pharmacological, and nutraceutical interventions aimed at reinstating the HSR in the context of chronic low-grade inflammation, as well as protocols to assess the HSR. Monitoring the progression or suppression of the HSR in patients and laboratory animals offers predictive insights into the organism’s capacity to combat chronic inflammation, as well as the impact of exercise and hyperthermic treatments (e.g., sauna or hot tub baths) on the HSR. Interestingly, a reciprocal correlation exists between the expression of HSR components in peripheral blood leukocytes (PBL) and the extent of local tissue proinflammatory activity in individuals afflicted by chronic inflammatory disorders. Therefore, the Heck index, contrasting extracellular 70 kDa family of heat shock proteins (HSP70) (proinflammatory) and intracellular HSP70 (anti-inflammatory) in PBL, serves as a valuable metric for HSR assessment. Our laboratory has also developed straightforward protocols for evaluating HSR by subjecting whole blood samples from both rodents and human volunteers to ex vivo heat challenges. Collectively, this discussion underscores the critical role of HSR disruption in the pathogenesis of chronic inflammatory states and emphasizes the significance of simple, cost-effective tools for clinical HSR assessment. This understanding is instrumental in the development of innovative strategies for preventing and managing chronic inflammatory diseases, which continue to exert a substantial global burden on morbidity and mortality.

Abstract Image

通过恢复热休克反应(HSR)解决慢性疾病中的炎症问题
通过热休克反应(HSR)有效缓解炎症是避免向慢性炎症状态过渡的关键。这种转变是一系列衰弱病症的特征,包括胰岛素抵抗、肥胖、2 型糖尿病、非酒精性脂肪肝和心血管疾病。本手稿探讨了一系列旨在恢复慢性低度炎症背景下 HSR 的生理、药理和营养干预措施,以及评估 HSR 的方案。通过监测患者和实验室动物体内 HSR 的进展或抑制情况,可以预测机体对抗慢性炎症的能力,以及运动和热疗(如桑拿浴或热水浴)对 HSR 的影响。有趣的是,慢性炎症患者外周血白细胞(PBL)中 HSR 成分的表达与局部组织促炎症活动的程度之间存在相互关系。因此,对比外周血白细胞中细胞外 HSP70(eHSP70,促炎)和细胞内 HSP70(iHSP70,抗炎)的 Heck 指数是评估 HSR 的重要指标。我们的实验室还制定了直接的方案,通过让啮齿动物和人类志愿者的全血样本接受体外热挑战来评估 HSR。总之,以上讨论强调了 HSR 干扰在慢性炎症发病机制中的关键作用,并强调了临床 HSR 评估所需的简单、经济有效工具的重要性。这种认识有助于开发预防和管理慢性炎症性疾病的创新策略,因为慢性炎症性疾病继续对全球的发病率和死亡率造成巨大负担。
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来源期刊
Cell Stress & Chaperones
Cell Stress & Chaperones 生物-细胞生物学
CiteScore
7.60
自引率
2.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.
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