Relationship between inflammatory laboratory parameters and severity of adolescent idiopathic scoliosis: A pilot study.

IF 1.4 4区医学 Q3 ORTHOPEDICS

Journal of Back and Musculoskeletal Rehabilitation Pub Date : 2024-01-01 DOI:10.3233/BMR-230186

Laura Bertelè, Valeria Giorgi, Paolo Bellavite, Giovanni Apostolo, Riccardo Ortolani, Alice Fila, Elisabetta Zanolin

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引用次数: 0

Abstract

Background: Adolescent idiopathic scoliosis is a complex condition whose pathogenesis may include inflammation and signs of joint and bone degeneration.

Objective: The main objective of this study is to evaluate the relationship between the severity of adolescent idiopathic scoliosis and inflammatory blood parameters.

Methods: The study recruited patients with adolescent idiopathic scoliosis who attended the Rehabilitation Center of the Apostolo Foundation in Merate (LC). The scoliosis curve (Cobb's angle) was used as a severity index to compare with inflammatory blood parameters (white blood cells subpopulations, immunoglobulins, protein electrophoresis). In addition, the study used an overall severity grading called "Scoliosis Score" which includes all spine angles and Risser's score (bone development index).

Results: Thirty-four subjects were recruited (mean age 14 years, 2 months), 30 females and 2 males. A significant correlation was found between Cobb's angle and the percentage values of beta-2 globulins in a directly proportional manner (r= 0.42, p= 0.01), and gamma globulins in an inversely proportional manner (r=-0.366, p= 0.04). However, no significant correlation between Cobb's angle and the absolute values of white blood cells and percentage subpopulations was found (r= 0.0821 p= 0.655). A moderate, inverse correlation was found between the Scoliosis Score and the percentage of neutrophils (r=-0.385, p= 0.02), a direct correlation was found between the Scoliosis Score and the percentage of lymphocytes (r= 0.404, p= 0.02). In addition, there was a strong correlation of the Scoliosis Score with alpha-2 globulin (r= 0.564, p= 0.0012), beta-1 globulin (r= 0.478, p= 0.0074), and beta-2 globulin (r= 0.370, p= 0.044) and an inverse relationship with gamma globulin (r=-0.625, p= 0.0002). The main correlations were confirmed by regression analysis.

Conclusion: The correlation between beta-2 globulins and gamma globulins with Cobb's angle and the Scoliosis Score suggests a link between spinal curvature and inflammation in scoliosis patients, This link may indicate the significance of these parameters for diagnosing, staging the disease, and monitoring therapies.

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炎症实验室参数与青少年特发性脊柱侧凸严重程度之间的关系：试点研究

背景：青少年特发性脊柱侧弯症是一种复杂的疾病，其发病机制可能包括炎症以及关节和骨骼退化的迹象：本研究的主要目的是评估青少年特发性脊柱侧弯症的严重程度与炎症性血液参数之间的关系：研究招募了在Merate（LC）阿波斯托罗基金会康复中心就诊的青少年特发性脊柱侧弯症患者。脊柱侧弯曲线（Cobb's 角）作为严重程度指数，与炎症性血液参数（白细胞亚群、免疫球蛋白、蛋白质电泳）进行比较。此外，该研究还采用了一个名为 "脊柱侧弯评分 "的整体严重程度分级，其中包括所有脊柱角度和里瑟评分（骨发育指数）：共招募了 34 名受试者（平均年龄 14 岁 2 个月），其中女性 30 名，男性 2 名。结果发现，科布氏角与β-2球蛋白的百分比值呈正比关系（r= 0.42，p= 0.01），与γ球蛋白呈反比关系（r=-0.366，p= 0.04）。然而，科布角与白细胞绝对值和亚群百分比之间没有发现明显的相关性（r= 0.0821 p=0.655）。脊柱侧弯评分与中性粒细胞百分比之间呈中度反相关（r=-0.385，p= 0.02），脊柱侧弯评分与淋巴细胞百分比之间呈直接相关（r= 0.404，p= 0.02）。此外，脊柱侧弯评分与α-2球蛋白（r= 0.564，p= 0.0012）、β-1球蛋白（r= 0.478，p= 0.0074）和β-2球蛋白（r= 0.370，p= 0.044）有很强的相关性，与γ球蛋白（r=-0.625，p= 0.0002）呈反向关系。回归分析证实了主要的相关性：结论：β-2球蛋白和γ球蛋白与科布氏角和脊柱侧弯评分之间的相关性表明，脊柱侧弯患者的脊柱弯曲与炎症之间存在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Back and Musculoskeletal Rehabilitation 医学-康复医学

CiteScore

2.70

自引率

0.00%

发文量

194

审稿时长

6 months

期刊介绍： The Journal of Back and Musculoskeletal Rehabilitation is a journal whose main focus is to present relevant information about the interdisciplinary approach to musculoskeletal rehabilitation for clinicians who treat patients with back and musculoskeletal pain complaints. It will provide readers with both 1) a general fund of knowledge on the assessment and management of specific problems and 2) new information considered to be state-of-the-art in the field. The intended audience is multidisciplinary as well as multi-specialty. In each issue clinicians can find information which they can use in their patient setting the very next day.