Magnetic resonance-guided focused ultrasound versus percutaneous thermal ablation in local control of bone oligometastases: a systematic review and meta-analysis

Abstract

Background

The percutaneous thermal ablation techniques (pTA) are radiofrequency ablation, cryoablation, and microwave ablation, suitable for the treatment of bone oligometastases. Magnetic resonance-guided focused ultrasound (MRgFUS) is a noninvasive ablation technique.

Objectives

To compare the effectiveness and safety of MRgFUS and pTA for treating bone oligometastases and their complications.

Methods

Studies were selected with a PICO/PRISMA protocol: pTA or MRgFUS in patients with bone oligometastases; non-exclusive curative treatment. Exclusion criteria were: primary bone tumor; concurrent radiation therapy; palliative therapy; and absence of imaging at follow-up. PubMed, BioMed Central, and Scopus were searched. The modified Newcastle–Ottawa Scale assessed articles quality. For each treatment (pTA and MRgFUS), we conducted two separate random-effects meta-analyses to estimate the pooled effectiveness and safety. The effectiveness was assessed by combining the proportions of treated lesions achieving local tumor control (LTC); the safety by combining the complications rates of treated patients. Meta-regression analyses were performed to identify any outcome predictor.

Results

A total of 24 articles were included. Pooled LTC rate for MRgFUS was 84% (N = 7, 95% CI 66–97%, I² = 74.7%) compared to 65% of pTA (N = 17, 95% CI 51–78%, I² = 89.3%). Pooled complications rate was similar, respectively, 13% (95% CI 1–32%, I² = 81.0%) for MRgFUS and 12% (95% CI 8–18%, I² = 39.9%) for pTA, but major complications were recorded with pTA only.

The meta-regression analyses, including technique type, study design, tumor, and follow-up, found no significant predictors.

Discussion

The effectiveness and safety of the two techniques were found comparable, even though MRgFUS is a noninvasive treatment that did not cause any major complication. Limited data availability on MRgFUS and the lack of direct comparisons with pTA may affect these findings.

Conclusions

MRgFUS can be a valid, safe, and noninvasive treatment for bone oligometastases. Direct comparison studies are needed to confirm its promising benefits.