A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development

IF 1.2 4区医学 Q4 CHEMISTRY, MEDICINAL

Letters in Drug Design & Discovery Pub Date : 2024-02-02 DOI:10.2174/0115701808287654240126112003

Mridula Chauhan, Shivansh Kumar, Arpon Biswas, Mukesh Kumar, Sarvesh Kumar Verma, Anjali Mishra, Vaishali Singh, Amol Chhatrapati Bisen, Sristi Agrawal, Abhijit Deb Choudhury, Ramkrishna Rayiti, Rabi Sankar Bhatta

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引用次数: 0

Abstract

: Discovering new drugs is time-consuming and expensive and involves many different tools from various domains. Numerous omic technologies, such as genomics, transcriptomics, proteomics, and metabolomics, have been created to speed up the process. Leveraging genetic and genomic insights, these methodologies play a pivotal role. Genetic insights aid in target identification, prioritization, and the prediction of drug outcomes. Gene expression data informs drug discovery, while proteomics uncovers targets and facilitates high-throughput profiling. Enhancing drug efficacy necessitates mechanistic insights into downstream effects, enabling side effects and resistance prediction. Early-stage drug discovery now extensively employs diverse metabolomics platforms. This review underscores the recent strides of omic technologies in drug discovery, affirming their role in enhancing drug viability and regulatory approval. The emphasis lies on the latest advancements in genomics, transcriptomics, proteomics, and metabolomics, collectively fortifying drug development.

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全面回顾药物发现和开发领域的 Omic 技术进展

:发现新药既费时又费钱，而且涉及不同领域的多种不同工具。基因组学、转录组学、蛋白质组学和代谢组学等众多 omic 技术的出现，加快了这一进程。利用基因和基因组学的洞察力，这些方法发挥着举足轻重的作用。基因洞察力有助于目标识别、优先排序和药物疗效预测。基因表达数据为药物发现提供了信息，而蛋白质组学则发现了靶点并促进了高通量分析。要提高药物疗效，就必须从机理上深入了解药物的下游效应，从而预测副作用和耐药性。早期药物发现目前广泛采用了各种代谢组学平台。本综述强调了 omic 技术在药物发现方面的最新进展，肯定了它们在提高药物可行性和监管审批方面的作用。重点是基因组学、转录组学、蛋白质组学和代谢组学的最新进展，它们共同加强了药物开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Letters in Drug Design & Discovery 医学-医药化学

CiteScore

1.80

自引率

10.00%

发文量

245

审稿时长

3 months

期刊介绍： Aims & Scope Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.