Thiourea-Ammonium Chloride Mediated Knoevenagel Condensation as an Intermediate in the Synthesis of Pyrimidine Scaffolds under Solvent-free Condition

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC

Letters in Organic Chemistry Pub Date : 2024-02-02 DOI:10.2174/0115701786286587240130114029

A. M. Rayate, M. R. Gaware

引用次数: 0

Abstract

: In this paper, we have reported solvent solvent-free method for Knoevenagel condensation reaction of various aldehydes with active methylene compounds using thiourea and ammonium chloride. The developed method demonstrated high efficiency in the formation of C-C bond. The reaction proceeds smoothly under mild and solvent-free conditions and the products obtained are in excellent yield in very short duration. This method is applicable to a wide range of aldehydes with active methylene compounds.

查看原文本刊更多论文

在无溶剂条件下以硫脲-氯化铵介导的克诺文纳格尔缩合为中间体合成嘧啶支架

:本文报告了使用硫脲和氯化铵进行各种醛与活性亚甲基化合物的克诺文纳格尔缩合反应的无溶剂方法。所开发的方法在形成 C-C 键方面表现出很高的效率。反应在温和、无溶剂的条件下顺利进行，并在极短的时间内获得了产率极高的产物。该方法适用于多种含有活性亚甲基化合物的醛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.