The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-02-03 DOI:10.2147/cia.s448354

Yue Wu, Siqi Cheng, Shaoyuan Lei, Dongxiao Li, Zhongzhong Li, Yansu Guo

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引用次数: 0

Abstract

Background: There is growing evidence that an antioxidant diet is a protective factor against frailty. However, few studies have examined the effect of comprehensive dietary antioxidants on frailty symptoms. The aim of this study was to examine the relationships between the composite dietary antioxidant index (CDAI) and frailty and the underlying mechanisms involved.
Methods: Based on the National Health and Nutrition Survey (NHANES) 2003– 2018, this study included 11,277 older persons aged ≥ 60 years. In this study, frailty was defined as having a total score > 0.21 on the 49-item frailty index. Six dietary antioxidants were selected for use in calculating the CDAI. A weighted multiple logistic regression model with subgroup analysis and restricted cubic splines (RCSs) were used to examine the association between the CDAI and frailty. To examine the role of oxidative stress, mediation analyses were also conducted.
Results: The association between the CDAI score and frailty risk was significant according to the multivariate model. Compared with participants in tertile 1, participants in both tertile 2 and tertile 3 had lower odds of developing frailty symptoms (OR=0.86; 95% CI=0.75– 0.97; P=0.02; and OR=0.81; 95% CI=0.70– 0.93; P=0.003). According to the subgroup analyses, the differences in interactions were not statistically significant. There was also a potential nonlinear relationship between the CDAI score and frailty risk. The serum albumin concentration and uric acid concentration had significant mediating effects on the association between the CDAI score and frailty index, with 19.25% (P=0.002) and 21.26% (P < 0.001) of the total, respectively.
Conclusion: Frailty is negatively associated with the CDAI score, which may be partially mediated by oxidative stress.

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膳食抗氧化剂综合指数与虚弱症状之间的关系：氧化应激的中介效应

背景：越来越多的证据表明，抗氧化饮食是防止虚弱的保护因素。然而，很少有研究探讨综合膳食抗氧化剂对虚弱症状的影响。本研究旨在探讨综合膳食抗氧化剂指数（CDAI）与虚弱之间的关系及其内在机制：本研究基于 2003-2018 年全国健康与营养调查（NHANES），纳入了 11277 名年龄≥ 60 岁的老年人。在这项研究中，虚弱被定义为在 49 项虚弱指数中总得分为 > 0.21。在计算 CDAI 时选择了六种膳食抗氧化剂。该研究采用了一个加权多元逻辑回归模型，并通过亚组分析和限制性立方样条（RCS）来研究 CDAI 与虚弱之间的关系。为了研究氧化应激的作用，还进行了中介分析：结果：根据多变量模型，CDAI 评分与虚弱风险之间的关系显著。与三等分 1 的参与者相比，三等分 2 和三等分 3 的参与者出现虚弱症状的几率较低（OR=0.86；95% CI=0.75-0.97；P=0.02；OR=0.81；95% CI=0.70-0.93；P=0.003）。根据亚组分析，交互作用的差异无统计学意义。CDAI 评分与虚弱风险之间也存在潜在的非线性关系。血清白蛋白浓度和尿酸浓度对CDAI评分和虚弱指数之间的关联有显著的中介作用，分别占总数的19.25%（P=0.002）和21.26%（P< 0.001）：虚弱与 CDAI 评分呈负相关，可能部分由氧化应激介导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.