Mapping the human brain proteome: opportunities, challenges, and clinical potential.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI:10.1080/14789450.2024.2313073

Paz Cartas-Cejudo, Adriana Cortés, Mercedes Lachén-Montes, Elena Anaya-Cubero, Erika Peral, Karina Ausín, Ramón Díaz-Peña, Joaquín Fernández-Irigoyen, Enrique Santamaría

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引用次数: 0

Abstract

Introduction: Due to the segmented functions and complexity of the human brain, the characterization of molecular profiles within specific areas such as brain structures and biofluids is essential to unveil the molecular basis for structure specialization as well as the molecular imbalance associated with neurodegenerative and psychiatric diseases.

Areas covered: Much of our knowledge about brain functionality derives from neurophysiological, anatomical, and transcriptomic approaches. More recently, laser capture and imaging proteomics, technological and computational developments in LC-MS/MS, as well as antibody/aptamer-based platforms have allowed the generation of novel cellular, spatial, and posttranslational dimensions as well as innovative facets in biomarker validation and druggable target identification.

Expert opinion: Proteomics is a powerful toolbox to functionally characterize, quantify, and localize the extensive protein catalog of the human brain across physiological and pathological states. Brain function depends on multi-dimensional protein homeostasis, and its elucidation will help us to characterize biological pathways that are essential to properly maintain cognitive functions. In addition, comprehensive human brain pathological proteomes may be the basis in computational drug-repositioning methods as a strategy for unveiling potential new therapies in neurodegenerative and psychiatric disorders.

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绘制人脑蛋白质组图谱：机遇、挑战和临床潜力。

导言：由于人脑的功能分区和复杂性，对特定区域（如大脑结构和生物流体）内的分子特征描述对于揭示结构特化的分子基础以及与神经退行性疾病和精神疾病相关的分子失衡至关重要：我们对大脑功能的了解大多来自神经生理学、解剖学和转录组学方法。最近，激光捕获和成像蛋白质组学、LC-MS/MS 的技术和计算发展，以及基于抗体/aptamer 的平台，使我们能够产生新的细胞、空间和翻译后维度，以及生物标记物验证和药物靶点识别的创新方面：蛋白质组学是一个功能强大的工具箱，可用于对人脑在生理和病理状态下的大量蛋白质进行功能表征、量化和定位。大脑功能取决于多维度的蛋白质平衡，对其进行阐明将有助于我们确定正常维持认知功能所必需的生物通路的特征。此外，全面的人脑病理蛋白质组可能是计算药物定位方法的基础，是揭示神经退行性疾病和精神疾病潜在新疗法的一种策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.