Chenyang Wu, Marc Xu, Junlin Dong, Wenqiang Cui, Shuguang Yuan
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引用次数: 0
Abstract
Olfactory receptors (ORs) form the most important chemosensory receptor family responsible for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the class A G protein-coupled receptors (GPCRs). Recent research has indicated that ORs are involved in many nonolfactory physiological processes in extranasal tissue, such as the brain, pancreas, and testes, and implies the possible role of their dysregulation in various diseases. The recently released structures of OR51E2 and consensus OR52 have also unveiled the uniqueness of ORs from other class A GPCR members. In this review, we discuss these recent developments and computational modeling efforts toward understanding the structural properties of unresolved ORs, which could guide potential future OR-targeted drug discovery.
嗅觉受体(OR)是鼻腔嗅觉上皮细胞中最重要的化学感觉受体家族,负责我们的嗅觉。该受体家族属于 A 类 G 蛋白偶联受体(GPCR)。最近的研究表明,ORs 参与了鼻腔外组织(如大脑、胰腺和睾丸)的许多非嗅觉生理过程,并暗示它们可能在各种疾病中发挥失调作用。最近公布的 OR51E2 和共识 OR52 的结构也揭示了 ORs 与其他 A 类 GPCR 成员的独特性。在这篇综述中,我们将讨论这些最新进展以及为了解未解决的 OR 结构特性而进行的计算建模工作,这将为未来潜在的 OR 靶向药物发现提供指导。
期刊介绍:
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.