Role of meningeal immunity in brain function and protection against pathogens.

IF 4.4 3区医学 Q2 IMMUNOLOGY

Journal of Inflammation-London Pub Date : 2024-01-30 DOI:10.1186/s12950-023-00374-7

Julie Rebejac, Elisa Eme-Scolan, Rejane Rua

引用次数: 0

Abstract

The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the last decade, many studies have emphasized the protective role of 'border regions' at the surface of the CNS which are highly immunologically active, in contrast with the CNS parenchyma. In the steady-state, lymphoid and myeloid cells residing in the cranial meninges can affect brain function and behavior. Upon infection, they provide a first layer of protection against microbial neuroinvasion. The maturation of border sites over time enables more effective brain protection in adults as compared to neonates. Here, we provide a comprehensive update on the meningeal immune system and its role in physiological brain function and protection against infectious agents.

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脑膜免疫在大脑功能和抵御病原体方面的作用。

大脑和脊髓统称为中枢神经系统（CNS），受到血脑屏障的保护，血脑屏障限制了分子、微生物和免疫物质的贩运。然而，在过去十年中，许多研究都强调了中枢神经系统表面 "边界区域 "的保护作用，与中枢神经系统实质形成鲜明对比的是，这些区域具有高度的免疫活性。在稳定状态下，驻留在颅骨脑膜上的淋巴细胞和骨髓细胞会影响大脑功能和行为。感染时，它们会提供第一层保护，防止微生物入侵神经。随着时间的推移，边界部位逐渐成熟，与新生儿相比，成年人能更有效地保护大脑。在此，我们将全面介绍最新的脑膜免疫系统及其在大脑生理功能和抵御感染病原体方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation-London IMMUNOLOGY-

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Inflammation welcomes research submissions on all aspects of inflammation. The five classical symptoms of inflammation, namely redness (rubor), swelling (tumour), heat (calor), pain (dolor) and loss of function (functio laesa), are only part of the story. The term inflammation is taken to include the full range of underlying cellular and molecular mechanisms involved, not only in the production of the inflammatory responses but, more importantly in clinical terms, in the healing process as well. Thus the journal covers molecular, cellular, animal and clinical studies, and related aspects of pharmacology, such as anti-inflammatory drug development, trials and therapeutic developments. It also considers publication of negative findings. Journal of Inflammation aims to become the leading online journal on inflammation and, as online journals replace printed ones over the next decade, the main open access inflammation journal. Open access guarantees a larger audience, and thus impact, than any restricted access equivalent, and increasingly so, as the escalating costs of printed journals puts them outside University budgets. The unrestricted access to research findings in inflammation aids in promoting dynamic and productive dialogue between industrial and academic members of the inflammation research community, which plays such an important part in the development of future generations of anti-inflammatory therapies.