Type IV pili of Enterobacteriaceae species.

Q1 Medicine

EcoSal Plus Pub Date : 2024-01-31 DOI:10.1128/ecosalplus.esp-0003-2023

Janay I Little, Pradip K Singh, Jinlei Zhao, Shakeera Dunn, Hanover Matz, Michael S Donnenberg

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引用次数: 0

Abstract

Type IV pili (T4Ps) are surface filaments widely distributed among bacteria and archaea. T4Ps are involved in many cellular functions and contribute to virulence in some species of bacteria. Due to the diversity of T4Ps, different properties have been observed for homologous proteins that make up T4Ps in various organisms. In this review, we highlight the essential components of T4Ps, their functions, and similarities to related systems. We emphasize the unique T4Ps of enteric pathogens within the Enterobacteriaceae family, which includes pathogenic strains of Escherichia coli and Salmonella. These include the bundle-forming pilus (BFP) of enteropathogenic E. coli (EPEC), longus (Lng) and colonization factor III (CFA/III) of enterotoxigenic E. coli (ETEC), T4P of Salmonella enterica serovar Typhi, Colonization Factor Citrobacter (CFC) of Citrobacter rodentium, T4P of Yersinia pseudotuberculosis, a ubiquitous T4P that was characterized in enterohemorrhagic E. coli (EHEC), and the R64 plasmid thin pilus. Finally, we highlight areas for further study.

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肠杆菌科物种的 IV 型纤毛虫。

第四型纤毛（T4Ps）是广泛分布于细菌和古细菌中的表面丝状物。T4Ps 参与了许多细胞功能，并对某些种类细菌的毒力有影响。由于 T4Ps 的多样性，在不同生物体中组成 T4Ps 的同源蛋白也具有不同的特性。在本综述中，我们将重点介绍 T4Ps 的基本成分、功能以及与相关系统的相似性。我们强调肠杆菌科肠道病原体（包括大肠杆菌和沙门氏菌的致病菌株）特有的 T4Ps。这些T4Ps包括肠致病性大肠杆菌（EPEC）的成束柔毛（BFP）、肠致病性大肠杆菌（ETEC）的长柔毛（Lng）和定植因子III（CFA/III）、肠致病性大肠杆菌（EPEC）和沙门氏菌（Salmonella）的T4Ps。大肠杆菌（ETEC）的 T4P、伤寒沙门氏菌（Salmonella enterica serovar Typhi）的 T4P、枸橼酸杆菌（Citrobacter rodentium）的定植因子（CFC）、耶尔森氏菌（Yersinia pseudotuberculosis）的 T4P、肠出血性大肠杆菌（EHEC）中的一种无处不在的 T4P 以及 R64 质粒细螺旋体。最后，我们强调了有待进一步研究的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EcoSal Plus Immunology and Microbiology-Microbiology

CiteScore

12.20

自引率

0.00%

发文量

期刊介绍： EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.