Bioactive compounds of Arctostaphylos uva-ursi wild-growing populations from Bulgaria

M. Nikolova, I. Aneva, P. Zhelev, S. Berkov, E. YANKOVA-TSVETKOVA
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引用次数: 0

Abstract

Arctostaphylos uva-ursi (L.) Sprengel (bearberry), Ericaceae is a valuable medicinal plant with diuretic and uroantiseptic action which is mainly due to arbutin. In Bulgaria the species is considered as rare. Content assessment of bioactive compounds of A. uva-ursi leaves from three natural populations from Bulgaria was the aim of the present study. Leaf samples were collected from Pirin, Vitosha, and Rhodope Mountains. Bioactive compounds in the methanolic extracts of the samples were analysed by GC/MS. Total phenolic content was determined using Folin–Ciocalteu reagent. Arbutin, quinic acid and gallic acid were detected in the highest amounts. Catechine, 4-hydroxybenzoic acid, chlorogenic acid, triterpenes (α- and β-amyrin, uvaol and lupeol) and other primary and secondary metabolites were found, also. Differences in the content of individual compounds between samples of different origin were established. The highest total phenolic (182.98 mg GAE g-1) and arbutin (8.4%) content was found in the sample from Vitosha Mountain. The presented data characterizes the profile of bioactive compounds in the Bulgarian bearberry raw material for the first time.
保加利亚野生欧鼠李的生物活性化合物
熊果(Arctostaphylos uva-ursi(L.)Sprengel,Ericaceae)是一种珍贵的药用植物,主要成分为熊果苷,具有利尿和杀菌作用。在保加利亚,该物种被视为珍稀物种。本研究的目的是评估保加利亚三个自然种群中熊果叶中生物活性化合物的含量。叶片样本采集自皮林山、维托沙山和罗多彼山脉。样品甲醇提取物中的生物活性化合物由 GC/MS 进行分析。使用 Folin-Ciocalteu 试剂测定总酚含量。检测到的熊果苷、奎宁酸和没食子酸含量最高。此外,还发现了儿茶酸、4-羟基苯甲酸、绿原酸、三萜类(α- 和 β-amyrin、uvaol 和 lupeol)以及其他初级和次级代谢产物。不同产地的样本在单个化合物含量上存在差异。维托沙山的样本中总酚(182.98 毫克 GAE g-1)和熊果苷(8.4%)含量最高。所提供的数据首次描述了保加利亚熊果原料中生物活性化合物的特征。
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来源期刊
International Journal of Secondary Metabolite
International Journal of Secondary Metabolite Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.40
自引率
0.00%
发文量
28
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