Relationship between vascular calcification, osteoporosis and systemic inflammation

K. A. Nichiporuk, S. Tsarenok, V. Gorbunov, N. A. Ilyamakova, T. Aksenova
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Abstract

A lot of patients with coronary heart disease often suffer from vascular calcification. In many cases it is accompanied by harmful cardiovascular events. The modern ideas of the relationship between osteoporosis, vascular calcification and inflammation, the general mechanisms of development of vascular calcification and low bone mineral density are discussed. Despite a growing number of studies concerning the combined pathology of the cardiovascular and skeletal systems, a causal relationship between vascular calcification and a decrease in bone mass has not yet been established. Moreover, there is insufficient data on the effect of inflammation on ectopic calcification. Based on the analysis of available clinical and experimental studies, this review describes the main pathogenetic mechanisms of vascular calcification in coronary atherosclerosis. The influence of calcium and vitamin D medicines on the development of vascular calcification is discussed in this article. The author’s attention is focused on early and long-term consequences of percutaneous coronary intervention and coronary bypass surgery in patients with vascular calcification.
血管钙化、骨质疏松症和全身炎症之间的关系
很多冠心病患者经常会出现血管钙化。在许多情况下,血管钙化伴随着有害的心血管事件。本文讨论了骨质疏松症、血管钙化和炎症之间关系的现代观点,以及血管钙化和低骨矿密度的一般发展机制。尽管有关心血管和骨骼系统综合病理的研究越来越多,但血管钙化与骨量下降之间的因果关系尚未得到证实。此外,关于炎症对异位钙化影响的数据也不充分。基于对现有临床和实验研究的分析,本综述描述了冠状动脉粥样硬化中血管钙化的主要致病机制。本文讨论了钙和维生素 D 药物对血管钙化发展的影响。作者关注的重点是血管钙化患者经皮冠状动脉介入治疗和冠状动脉搭桥手术的早期和长期后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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